Martina Cappello
5 Papers
Martina Cappello is an academic researcher. The author has contributed to research in topics: Adenosine & Adenosine receptor. The author has an hindex of 1, co-authored 2 publications.
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Papers
Update on the recent development of allosteric modulators for adenosine receptors and their therapeutic applications
Silvia Pasquini,Chiara Contri,Martina Cappello,Pier Andrea Borea,Katia Varani,Fabrizio Vincenzi +5 more
TL;DR: Data in the literature suggests that allosteric modulators of ARs could represent valuable pharmacological tools, potentially able to overcome the limitations of orthosteric ligands.
Pharmacology of Adenosine Receptors: Recent Advancements
Fabrizio Vincenzi,Silvia Pasquini,Chiara Contri,Martina Cappello,Manuela Nigro,Alessia Travagli,Stefania Merighi,Stefania Gessi,Pier Andrea Borea,Katia Varani +9 more
TL;DR: The latest studies discussed herein shed light on novel mechanisms through which ARs exert control over pathophysiological states, and introduce new ligands and innovative strategies for receptor activation, presenting compelling evidence of efficacy along with the implicated signaling pathways.
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A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients.
Sara Rossi,Vanessa Tatangelo,Maria Dichiara,Stefania Butini,Sandra Gemma,Simone Brogi,Silvia Pasquini,Martina Cappello,Fabrizio Vincenzi,Katia Varani,Ludovica Lopresti,Margherita Malchiodi,Chiara Carrara,Alessandro Gozzetti,Monica Bocchia,Giuseppe Marotta,Laura Patrussi,Gabriele Carullo,Cosima T. Baldari,Giuseppe Campiani +19 more
- 04 Apr 2024
TL;DR: HDAC1 inhibition is necessary to reactivate STAT4/p66Shc expression in patients with CLL and 6c is one of the most potent HDAC1is known to date and represents a novel pharmacological tool for reversing the impairment of the STAT4/p66Shc apoptotic machinery.
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Caffeine for Prevention of Alzheimer’s Disease: Is the A2A Adenosine Receptor Its Target?
Stefania Merighi,Alessia Travagli,Manuela Nigro,Silvia Pasquini,Martina Cappello,Chiara Contri,Katia Varani,Fabrizio Vincenzi,Pier Andrea Borea,Stefania Gessi +9 more
TL;DR: In this paper , a review provides a summary of the scientific data supporting the critical role that A2ARs play in memory loss and cognitive decline, as well as the evidence supporting the protective benefits against neurodegeneration that may be attained by caffeine's antagonistic action on these receptors.
Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents.
Alessandro Papa,Ilaria Cursaro,Luca Pozzetti,Chiara Contri,Martina Cappello,Silvia Pasquini,Gabriele Carullo,Anna Ramunno,Sandra Gemma,Katia Varani,Stefania Butini,Giuseppe Campiani,Fabrizio Vincenzi +12 more
TL;DR: The design, synthesis, and biological evaluation of the first‐in‐class FAAH‐HDAC multitarget inhibitors are reported, showing a balanced nanomolar inhibitory activity against the selected targets and outperforming the standard antioxidant N‐acetylcysteine in vitro.