Martin Schubert
University of Jena
15 Papers
30 Citations
Martin Schubert is an academic researcher from University of Jena. The author has contributed to research in topics: Vitamin E & Lipid metabolism. The author has an hindex of 6, co-authored 13 publications.
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Papers
Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?
Martin Schubert,Stefan Kluge,Lisa Schmölz,Maria Wallert,Maria Wallert,Francesco Galli,Marc Birringer,Stefan Lorkowski +7 more
TL;DR: It could be proposed that the mode of action of the LCMs might be mediated by a mechanism similar to vitamin A and D metabolites, and a general concept of activation of lipid-soluble vitamins via their metabolites might be deduced.
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Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients
Sijia Liao,Sylvia Oghogho Omage,Lisa Börmel,Stefan Kluge,Martin Schubert,Maria rer. nat. Wallert,Stefan Lorkowski +6 more
TL;DR: In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.
The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response.
Maria Wallert,Julia Bauer,Stefan Kluge,Lisa Schmölz,Yung-Chih Chen,Melanie Ziegler,Amy Kate Searle,Alexander Maxones,Martin Schubert,Maria Thürmer,Helmut Pein,Andreas Koeberle,Oliver Werz,Marc Birringer,Karlheinz Peter,Stefan Lorkowski +15 more
TL;DR: This study provides molecular insights into the anti-inflammatory activities of Garcinia kola and reveals GA as promising natural lead for the development of multi-target drugs to treat inflammation-driven diseases.
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The Peroxisome Proliferator–Activated Receptor (PPAR)-γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPARδ and Induces Lipogenesis and Triglyceride Accumulation in Human THP-1 Macrophages
Martin Schubert,Stefanie Becher,Maria Wallert,Marten B. Maeß,Masoumeh Abhari,Knut Rennert,Alexander S. Mosig,Silke Große,Regine Heller,Michael Grün,Stefan Lorkowski +10 more
TL;DR: Deep and unexpected off-target effects of the PPARγ antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662) involving PPARδ and in turn affecting macrophage lipid metabolism are described.
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Long-chain metabolites of vitamin E: Interference with lipotoxicity via lipid droplet associated protein PLIN2.
Lisa Schmölz,Martin Schubert,Jasmin Kirschner,Stefan Kluge,Francesco Galli,Marc Birringer,Maria Wallert,Stefan Lorkowski +7 more
TL;DR: It is concluded that α-13'-COOH protects cells from lipotoxicity, at least partially via PLIN2 regulation, and their reputation as regulatory metabolites was further established.
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