Martin Peterka
ETH Zurich
6 Papers
28 Citations
Martin Peterka is an academic researcher from ETH Zurich. The author has contributed to research in topics: Microtubule & Mitochondrial transport. The author has an hindex of 3, co-authored 6 publications. Previous affiliations of Martin Peterka include École Polytechnique Fédérale de Lausanne.
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Papers
CENP-F couples cargo to growing and shortening microtubule ends.
Gil Kanfer,Martin Peterka,Vladimir K. Arzhanik,Alexei L. Drobyshev,Fazly I. Ataullakhanov,Vladimir A. Volkov,Benoît Kornmann +6 more
TL;DR: Unlike canonical transport, in which cargo is attached to molecular motors, CENP-F promotes the transport of cargoes by directly attaching them to the tips of growing and shrinking microtubules.
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CENP-F couples cargo to growing and shortening microtubule ends
Gil Kanfer,Martin Peterka,Vladimir K. Arzhanik,Alexei L. Drobyshev,Fazly I. Ataullakhanov,Vladimir A. Volkov,Benoît Kornmann +6 more
TL;DR: In vitro reconstitution demonstrates that microtubule tips can transport mitochondria and CENP-F-coated artificial cargoes over micrometer-long distances, during both growing and shrinking phases, and suggests that CENp-F might act as a transporter of mitochondrial and other cellular cargoe by attaching them to dynamic microtubules ends.
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Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice.
Martin Peterka,Benoît Kornmann +1 more
TL;DR: This work engineer a CENP-F point-mutant that is deficient in Miro binding and thus is unable to localize to mitochondria, but retains other localizations and introduces this mutation in cultured human cells using CRISPR/Cas9 system and shows a defect in mitochondrial spreading similar to that observed upon Miro depletion.
Harnessing DSB repair to promote efficient homology-dependent and -independent prime editing
Martin Peterka,Nina Akrap,Songyuan Li,Sandra Wimberger,Pei-Pei Hsieh,Dmitrii Degtev,Burcu Bestas,Jack Barr,Stijn van de Plassche,Patricia Mendoza-Garcia,Saša Šviković,Grzegorz Sienski,Mike Firth,Marcello Maresca +13 more
TL;DR: In this article, the authors exploit DNA double-strand break (DSB) repair to develop two novel strategies that install precise genomic insertions using an SpCas9 nuclease-based prime editor.
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Miro-dependent mitochondrial pool of CENP-F and its farnesylated C-terminal domain are dispensable for normal development in mice
Martin Peterka,Benoît Kornmann +1 more
TL;DR: This work engineer a CENP-F point-mutant that is deficient in Miro binding and thus is unable to localize to mitochondria, but retains other localizations and introduces this mutation in cultured human cells using CRISPR/Cas9 and shows it causes a defect in mitochondrial spreading similar to that observed upon Miro depletion.