Martin Lücke
University of Münster
6 Papers
36 Citations
Martin Lücke is an academic researcher from University of Münster. The author has contributed to research in topics: PEGylation & Medicine. The author has an hindex of 5, co-authored 6 publications.
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Papers
A new mechanism preventing proarrhythmia in chronic heart failure: rapid phase-III repolarization explains the low proarrhythmic potential of amiodarone in contrast to sotalol in a model of pacing-induced heart failure.
Gerrit Frommeyer,Peter Milberg,Patricia Witte,Jörg Stypmann,Matthias Koopmann,Martin Lücke,Nani Osada,Günter Breithardt,Michael Fehr,Lars Eckardt +9 more
TL;DR: The aim of the present study was to investigate the mechanism underlying the low proarrhythmic potential of amiodarone in a model of pacing‐induced heart failure.
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Anticancer Therapy by Tumor Vessel Infarction with Polyethylene Glycol Conjugated Retargeted Tissue Factor
Christian Schwöppe,Caroline Zerbst,Max Fröhlich,Christoph Schliemann,Torsten Kessler,Ruediger Liersch,Laura Overkamp,Richard Holtmeier,Jörg Stypmann,Alena Dreiling,Simone König,Carsten Höltke,Martin Lücke,Carsten Müller-Tidow,Rolf M. Mesters,Wolfgang E. Berdel +15 more
TL;DR: Results demonstrate that PEGylation can significantly improve the therapeutic range of tTF-NGR and comparison of the LD10 values for both compounds showed an improved therapeutic range.
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Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia.
Christian Ertmer,Andrea Morelli,Hans-Georg Bone,Henning D. Stubbe,Ralf Schepers,Hugo Van Aken,Matthias Lange,Katrin Bröking,Martin Lücke,Daniel L. Traber,Martin Westphal +10 more
TL;DR: Evidence is provided that dobutamine is a useful agent for reversing the AVP-associated impairment in systemic blood flow and global oxygen transport in an established model of ovine endotoxemia.
Tumor Growth Inhibition via Occlusion of Tumor Vasculature Induced by N-Terminally PEGylated Retargeted Tissue Factor tTF-NGR.
Caroline Brand,Max Fröhlich,Janine Ring,Christoph Schliemann,Torsten Kessler,Verena Mantke,Simone König,Martin Lücke,Rolf M. Mesters,Wolfgang E. Berdel,Christian Schwöppe +10 more
TL;DR: PEG20k-tTF-NGR showed clear antitumor efficacy in vivo against human tumor xenografts when systemically applied and site-directed mono-PEGylation to the N-terminus does not unequivocally improve the therapeutic profile of tTF- NGR.
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Hemodynamic effects of titrated norepinephrine in healthy versus endotoxemic sheep.
Matthias Lange,Katrin Bröking,C. Hucklenbruch,Christian Ertmer,Hugo Van Aken,Martin Lücke,Hans-Georg Bone,Martin Westphal +7 more
TL;DR: It is demonstrated that the presence of systemic inflammation leads to an early hyporesponsiveness against norepinephrine which was caused by a drug-independent mechanism rather than a tachyphylaxis due to long-term administration of nore Pinephrine.
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