Martin Hesseler
University of Greifswald
13 Papers
107 Citations
Martin Hesseler is an academic researcher from University of Greifswald. The author has contributed to research in topics: Chemistry & Protein engineering. The author has an hindex of 8, co-authored 13 publications.
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Papers
Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel
Tana Koudelakova,Radka Chaloupková,Jan Brezovsky,Zbynek Prokop,Eva Sebestova,Martin Hesseler,Morteza Khabiri,Maryia Plevaka,Daryna Kulik,Ivana Kuta Smatanova,Ivana Kuta Smatanova,Pavlina Rezacova,Rüdiger Ettrich,Uwe T. Bornscheuer,Jiri Damborsky +14 more
TL;DR: Protein crystallography and molecular dynamics revealed that the tunnel residue packing is a key determinant of protein stability and the active-site accessibility for co-solvent molecules.
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Protein Engineering of α/β‐Hydrolase Fold Enzymes
Helge Jochens,Martin Hesseler,Konstanze Stiba,Santosh Kumar Padhi,Romas J. Kazlauskas,Uwe T. Bornscheuer +5 more
TL;DR: This minireview covers methods developed for efficient protein engineering of α/β‐hydrolase fold enzymes, and concepts for the investigation of the evolutionary relationship between the different members of this protein superfamily.
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Enzymatic removal of 3-monochloro-1,2-propanediol (3-MCPD) and its esters from oils
TL;DR: An easy enzymatic way to remove 3-MCPD and its esters from the reaction media by converting it to the nontoxic glycerol is presented, which requires neither high temperature nor organic solvents.
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Hydrophobic microenvironment optimization for efficient immobilization of lipases on octadecyl functionalised resins
TL;DR: A novel family of spherical beads made of octadecyl (OD) functionalised methacrylic resins for lipase immobilization was developed and activity of the immobilized lipase reflected the effect of OD functional groups density on the hydrophobic microenvironment.
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Protein Engineering of α/β-Hydrolase Fold Enzymes
Helge Jochens,Martin Hesseler,Konstanze Stiba,Santosh Kumar Padhi,Romas J. Kazlauskas,Uwe T. Bornscheuer +5 more
TL;DR: The α/β-hydrolase fold enzymes are one of the largest known protein families, including a broad range of synthetically useful enzymes such as lipases, esterases, amidases, hydroxynitrile lyases, epoxide hydrolases and dehalogenases.
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