Martin Hapke
Hannover Medical School
11 Papers
22 Citations
Martin Hapke is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Adoptive cell transfer & Antigen. The author has an hindex of 8, co-authored 11 publications.
Chat about Author
Papers
GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
Tibor Kempf,Alexander Zarbock,Christian Widera,Stefan Butz,Anika Stadtmann,Jan Rossaint,Matteo Bolomini-Vittori,Mortimer Korf-Klingebiel,L. Christian Napp,Birte Hansen,Anna Kanwischer,Udo Bavendiek,Gernot Beutel,Martin Hapke,Martin Sauer,Carlo Laudanna,Nancy Hogg,Dietmar Vestweber,Kai C. Wollert +18 more
TL;DR: GDF-15 is the first cytokine identified as an inhibitor of PMN recruitment by direct interference with chemokine signaling and integrin activation, and loss of this anti-inflammatory mechanism leads to fatal cardiac rupture after myocardial infarction.
493
Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes.
Michel Tenspolde,Katharina Zimmermann,Leonie C. Weber,Martin Hapke,Maren Lieber,Janine Dywicki,André Frenzel,Michael Hust,Melanie Galla,Laura Elisa Buitrago-Molina,Michael P. Manns,Elmar Jaeckel,Matthias Hardtke-Wolenski,Matthias Hardtke-Wolenski +13 more
TL;DR: The data demonstrate that the converted, insulin-specific CAR Tregs (cTregs) were functional stable, suppressive and long-lived in vivo, and a proof of concept for both redirection of T cell specificity and conversion of Teffs to cT Regs.
157
PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells
Wolfgang Koestner,Martin Hapke,Jessica Herbst,Christoph Klein,Karl Welte,Joerg Fruehauf,Andrew Flatley,Dario A. A. Vignali,Matthias Hardtke-Wolenski,Elmar Jaeckel,Bruce R. Blazar,Martin Sauer +11 more
TL;DR: A clinical approach is suggested in which the AT of gene-modified allogeneic T cells early after transplantation can provide a potent GVL effect without GVHD, whereas later AT is effective only with concurrent PD-L1 blockade.
81
Donor T cells primed on leukemia lysate-pulsed recipient APCs mediate strong graft-versus-leukemia effects across MHC barriers in full chimeras.
Arnab Ghosh,Wolfgang Koestner,Martin Hapke,Verena Schlaphoff,Florian Länger,Rolf Baumann,Christian Koenecke,Markus Cornberg,Karl Welte,Bruce R. Blazar,Martin Sauer +10 more
TL;DR: It is shown that in vitro priming of donor lymphocytes can circumvent the need of recipient-derived APCs in vivo for mediating robust GVL effects and significantly diminishes the risk of severe GVHD.
18
Hepatic T Cell Tolerance Induction in An Inflammatory Environment.
Janine Dywicki,Fatih Noyan,Ana Clara Misslitz,Martin Hapke,Melanie Galla,Jerome Schlue,Roland S. Liblau,Richard Taubert,Michael P. Manns,Elmar Jaeckel,Matthias Hardtke-Wolenski +10 more
TL;DR: A system where the model antigen hemagglutinin is expressed exclusively in hepatocytes of Rosa26-HA mice following administration of a replication deficient adenovirus expressing Cre recombinase is established, highlighting the crucial importance of genetic susceptibility to break tolerance against hepatic autoantigens.
9