A new program for treating advanced Hodgkin's disease (mostly stage IIIB and IV) employs five drugs and low dose radiotherapy. Three cycles of nitrogen mustard, vincristine, procarbazine, vinblastine and prednisone are given over six months, followed by 1,500–2,500 rads to all diseased areas. Following radiotherapy, two additional cycles of chemotherapy are given. Of 34 patients in this program, 25 have completed three cycles (six months) of drug treatment plus irradiation. Twenty of the 25 are in complete remission, continually free of disease, with a median duration of 12+ months. The principal toxic manifestation of the program is bone marrow depression.

Low dose radiation therapy and combination chemotherapy in the treatment of advanced Hodgkin's disease.

Thirteen of 22 patients with widespread Hodgkin's disease resistant to vinca alkaloids and alkylating agents responded to therapy with procarbazine hydrochloride. All responses were clinically evident three weeks after therapy was begun. Four complete and nine partial remissions were achieved ranging from 4 to more than 40 weeks in duration with a median duration of 10 weeks. The relatively short duration of response and the paucity of complete remissions in these patients may be related to the severity of the disease. Procarbazine hydrochloride has been demonstrated to be a safe, effective agent in the drug management of advanced Hodgkin's disease.

Procarbazine in the Management of Late Hodgkin's Disease

The Yale combination chemotherapy program for advanced Hodgkin's disease. A preliminary report.

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The Yale combination chemotherapy program for advanced Hodgkin's disease. A preliminary report.