Marla Pyle
Kansas State University
37 Papers
225 Citations
Marla Pyle is an academic researcher from Kansas State University. The author has contributed to research in topics: Stem cell & Medicine. The author has an hindex of 18, co-authored 32 publications.
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Papers
Attenuation of mouse melanoma by A/C magnetic field after delivery of bi-magnetic nanoparticles by neural progenitor cells.
Raja Shekar Rachakatla,Sivasai Balivada,Gwi-Moon Seo,Carl B. Myers,Hongwang Wang,Thilani N. Samarakoon,Raj Kumar Dani,Marla Pyle,Franklin Orban Kroh,Brandon Walker,Xiaoxuan Leaym,Olga Koper,Viktor Chikan,Stefan H. Bossmann,Masaaki Tamura,Deryl L. Troyer +15 more
TL;DR: The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors.
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Combination Treatment of Human Umbilical Cord Matrix Stem Cell-Based Interferon-Beta Gene Therapy and 5-Fluorouracil Significantly Reduces Growth of Metastatic Human Breast Cancer in SCID Mouse Lungs
Raja Shekar Rachakatla,Marla Pyle,Rie Ayuzawa,Sarah M. Edwards,Frank C. Marini,Mark L. Weiss,Masaaki Tamura,Deryl L. Troyer +7 more
TL;DR: Although both treatments significantly reduced MDA 231 tumor area in the SCID mouse lungs, the combined treatment resulted in a greater reduction in tumor area than by either treatment used alone.
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Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells
Lei Wang,Ziyan Liu,Sivasai Balivada,Tej B. Shrestha,Stefan H. Bossmann,Marla Pyle,Loretta Pappan,Jishu Shi,Deryl L. Troyer +8 more
TL;DR: This finding indicates thatglioma cells without self-renewal capability in standard conditions could also contribute to glioma malignancy when cytokines, such as IL-1β and TGF-β, are present in the tumor environment.
Magnetic-Fe/Fe(3)O(4)-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages
Hongwang Wang,Tej B. Shrestha,Matthew T. Basel,Raj Kumar Dani,Gwi-Moon Seo,Sivasai Balivada,Marla Pyle,Heidy Prock,Olga Koper,Prem S. Thapa,David S. Moore,Ping Li,Viktor Chikan,Deryl L. Troyer,Stefan H. Bossmann +14 more
TL;DR: The synthesis of a nanoplatform, which is composed of a 15 ± 1 nm diameter core/shell Fe/Fe3O4 magnetic nanoparticles (MNPs) and the topoisomerase I blocker SN38 bound to the surface of the MNPs via a carboxylesterase cleavable linker, which demonstrated high heating ability in an AC-magnetic field.
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Cytotherapy with naive rat umbilical cord matrix stem cells significantly attenuates growth of murine pancreatic cancer cells and increases survival in syngeneic mice
TL;DR: It is indicated that naive rat UCMSC alone remarkably attenuate the growth of pancreatic carcinoma cells in vitro and in a mouse peritoneal model, implying that UC MSC could be a potential tool for targeted cytotherapy for pancreatic cancer.
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