Markus Wölfel

TL;DR: A simple modification is described that enables simultaneous, long-term imaging of all cortical layers and electrophysiology and calcium imaging of evoked and endogenous activity near the prism face were consistent across days and comparable with previous observations.

TL;DR: In this paper, simple glass structures, such as plugs, prisms, and prism-plug combinations, were used for chronic in vivo multiphoton microscopy of cortical and sub-cortical structures with high-resolution and large fields-of-view.

TL;DR: Local inhibitory-to-excitatory wiring patterns in all principal layers of primary motor, somatosensory and visual cortex are delineated and compared using genetically targeted photostimulation in a mouse knock-in line that conditionally expresses channelrhodopsin-2 in GABAergic neurons.

TL;DR: It is shown that, in young mice, deletion of CSPα does not impair survival and causes no significant changes in presynaptic Ca 2+ currents or synaptic vesicle exocytosis as measured in the Calyx of Held synapse, suggesting that enhanced CSP α function could attenuate neurodegenerative diseases.