Markus Schulz
Bosch
19 Papers
79 Citations
Markus Schulz is an academic researcher from Bosch. The author has contributed to research in topics: Genotoxicity & Micronucleus test. The author has an hindex of 13, co-authored 19 publications.
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Papers
Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats
Markus Schulz,Lan Ma-Hock,Sandra Brill,Volker Strauss,Silke Treumann,Sibylle Gröters,Bennard van Ravenzwaay,Robert Landsiedel +7 more
TL;DR: In conclusion, under the conditions of this study the different sized gold NP tested were non-genotoxic and showed no systemic and local adverse effects at the given dose.
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In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials.
Elena Maser,Markus Schulz,Ursula G. Sauer,Martin Wiemann,Lan Ma-Hock,Wendel Wohlleben,Andrea Hartwig,Robert Landsiedel +7 more
TL;DR: The study shows that colloidal amorphous SiO2 with different particle sizes may induce genotoxic effects in lung cells in vitro at comparatively high concentrations, even though pronounced pulmonary inflammation evolved in the rat lung.
77
Refinement and reduction of acute oral toxicity testing: a critical review of the use of cytotoxicity data.
Arnhild Schrage,Katja Hempel,Markus Schulz,Susanne N. Kolle,Bennard van Ravenzwaay,Robert Landsiedel +5 more
TL;DR: The neutral red uptake (NRU) method and 3T3 NRU cytotoxicity data alone did not sufficiently contribute to refinement and reduction in the acute oral toxicity testing of the substance portfolio tested routinely in the laboratory.
54
Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility.
Kerstin Reisinger,V. Blatz,Joep Brinkmann,Thomas R. Downs,Anja Fischer,Frank Henkler,Sebastian Hoffmann,Cyrille Krul,Manfred Liebsch,Andreas Luch,Ralph Pirow,Astrid A. Reus,Markus Schulz,Stefan Pfuhler +13 more
TL;DR: The data are intended to demonstrate the use of the 3D Skin Comet assay as a new in vitro tool for following up on positive findings from the standard in vitro genotoxicity test battery for dermally applied chemicals, ultimately helping to drive the regulatory acceptance of the assay.
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No genotoxicity in rat blood cells upon 3- or 6-month inhalation exposure to CeO2 or BaSO4 nanomaterials
Eugenia Cordelli,Jana Keller,Patrizia Eleuteri,Paola Villani,Lan Ma-Hock,Markus Schulz,Robert Landsiedel,Francesca Pacchierotti +7 more
TL;DR: It is demonstrated that subchronic inhalation exposure to different low doses of CeO2 or to a high dose of BaSO4 nanomaterials does not induce genotoxicity on the rat hematopoietic system at the DNA, gene or chromosome levels.