Markus Schneider
Goethe University Frankfurt
7 Papers
Markus Schneider is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Medicine & Exome sequencing. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Markus Schneider include University of Duisburg-Essen.
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Papers
Microsatellite Instability Occurs Rarely in Patients with Cholangiocarcinoma: A Retrospective Study from a German Tertiary Care Hospital
Ria Winkelmann,Markus Schneider,Sylvia Hartmann,Andreas A. Schnitzbauer,Stefan Zeuzem,Jan Peveling-Oberhag,Jan Peveling-Oberhag,Martin-Leo Hansmann,Dirk Walter +8 more
TL;DR: Microsatellite instability (MSI) seems to appear rarely in CCA in Germany, which should be considered when planning immune-modulating therapy trials for patients with CCA.
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An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma
Anna Lollies,Sylvia Hartmann,Markus Schneider,Markus Schneider,Thilo Bracht,Weiß Al,Judith Arnolds,Ludger Klein-Hitpass,Barbara Sitek,M. L. Hansmann,Ralf Küppers,Marc A. Weniger +11 more
TL;DR: STAT-mediated BATF3 expression that is essential for lymphoma cell survival and promoted MYC activity in cHL and ALCL is identified, hence a new oncogenic axis in these lymphomas is recognized.
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Intratumoral heterogeneity of intrahepatic cholangiocarcinoma
Dirk Walter,Claudia Döring,Magdalena Feldhahn,Florian Battke,Sylvia Hartmann,Ria Winkelmann,Markus Schneider,Katrin Bankov,Andreas A. Schnitzbauer,Stefan Zeuzem,Martin-Leo Hansmann,Jan Peveling-Oberhag,Jan Peveling-Oberhag +12 more
TL;DR: iCCA show a small but distinct intratumoral heterogeneity and Somatic mutations in mismatch repair proteins might contribute significantly to increased spatial tumor burden and thereby may influence clinical management.
A high number of IgG4-positive plasma cells rules out nodular lymphocyte predominant Hodgkin lymphoma
Kati Kiil,Julia Bein,Bianca Schuhmacher,Lorenz Thurner,Markus Schneider,Martin-Leo Hansmann,Sylvia Hartmann +6 more
TL;DR: IgG4’s inefficiency in clearing antigens may explain why lymph nodes with PTGC are usually strongly enlarged and develop a high number of hyperplastic germinal centers and polyclonal immunoglobulin heavy chain rearrangements in IgG4-positive plasma cells further support the hypothesis that PTGC represent a misled immune reaction.
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Sequencing of intraductal biopsies is feasible and potentially impacts clinical management of patients with indeterminate biliary stricture and cholangiocarcinoma.
Katrin Bankov,Claudia Döring,Markus Schneider,Sylvia Hartmann,Ria Winkelmann,Joerg G. Albert,Joerg G. Albert,Wolf O. Bechstein,Stefan Zeuzem,Martin-Leo Hansmann,Jan Peveling-Oberhag,Jan Peveling-Oberhag,Dirk Walter +12 more
TL;DR: This is the first to demonstrate the feasibility of sequencing of intraductal biopsies which holds the potential to impact diagnostic and therapeutical management of patients with biliary dysplasia and neoplasia and potentially improves the diagnostic yield.
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