Markus Räsänen
University of Helsinki
15 Papers
Markus Räsänen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Markus Räsänen include University of Bern.
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Papers
A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.
Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.
Liqun He,Michael Vanlandewijck,Michael Vanlandewijck,Maarja Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Åsa Segerstolpe,Jianping Liu,Sonja Gustafsson,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +23 more
TL;DR: The dataset constitutes a comprehensive molecular atlas of vascular and vessel-associated cell types in the mouse brain and lung, and as such provides a strong foundation for future studies of vascular development and diseases.
VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
Riikka Kivelä,Maija Bry,Marius R. Robciuc,Markus Räsänen,Miia Taavitsainen,Johanna M.U. Silvola,Antti Saraste,Juha J. Hulmi,Andrey Anisimov,Mikko I. Mäyränpää,Mikko I. Mäyränpää,Jan H.N. Lindeman,Lauri Eklund,Sanna Hellberg,Ruslan Hlushchuk,Zhen W. Zhuang,Michael Simons,Valentin Djonov,Juhani Knuuti,Eero Mervaala,Kari Alitalo +20 more
TL;DR: The data indicate that VEGF‐B could be used to increase the coronary vasculature and to reprogram myocardial metabolism to improve cardiac function in ischemic heart disease.
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VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration.
Markus Räsänen,Ibrahim Sultan,Jennifer Paech,Karthik Amudhala Hemanthakumar,Wei Yu,Liqun He,Liqun He,Juan Tang,Ying Sun,Ruslan Hlushchuk,Xiuzheng Huan,Emma Armstrong,Oleksiy-Zakhar Khoma,Eero Mervaala,Valentin Djonov,Christer Betsholtz,Bin Zhou,Riikka Kivelä,Kari Alitalo +18 more
TL;DR: The myocardial VEGF-B transgene promotes the formation of endocardium-derived coronary vessels during development, endothelial proliferation in subendocardial myocardium in adult mice, and structural and functional rescue of cardiac tissue after myocardIAL infarction.
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Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes
Tuuli A. Nissinen,Joni Degerman,Markus Räsänen,A. R. Poikonen,S. O. A. Koskinen,Eero Mervaala,Arja Pasternack,Olli Ritvos,Riikka Kivelä,Juha J. Hulmi,Juha J. Hulmi +10 more
TL;DR: It is demonstrated that blocking ACVR2B signalling may be a promising strategy to counteract chemotherapy-induced muscle wasting without damage to skeletal muscle oxidative capacity or cancer treatment.