8 Papers
Markus Luchner is an academic researcher from University of Natural Resources and Life Sciences, Vienna. The author has contributed to research in topics: Escherichia coli & Mass spectrometry. The author has an hindex of 5, co-authored 8 publications.
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Papers
Evaluation of three industrial Escherichia coli strains in fed-batch cultivations during high-level SOD protein production
TL;DR: This study directly compared the T7-based expression hosts E. coli BL21, RV308, and HMS174, focusing on evaluating the specific attributes of these strains in relation to high-level protein production of the model protein recombinant human superoxide dismutase (SOD).
Implementation of proton transfer reaction‐mass spectrometry (PTR‐MS) for advanced bioprocess monitoring
Markus Luchner,Rene Gutmann,Karl Bayer,Jürgen Dunkl,Armin Hansel,Jens Herbig,W Singer,Florian Strobl,Klaus Winkler,Gerald Striedner +9 more
TL;DR: The presented results clearly show that PTR‐MS was successfully implemented as a powerful bioprocess‐monitoring tool and that access to volatiles emitted by the cells opens promising perspectives in terms of advanced process control.
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Boosted structured additive regression for Escherichia coli fed-batch fermentation modeling.
TL;DR: In this article, the authors explore structured additive regression (STAR) models in combination with boosting as a variable selection tool for modeling the cell dry mass, product concentration, and optical density on the basis of online available process variables and two-dimensional fluorescence spectroscopic data.
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Online prediction of product titer and solubility of recombinant proteins in Escherichia coli fed‐batch cultivations
TL;DR: The application of advanced process monitoring concepts comprising recently established analytical targets and statistical modeling allows for real-time prediction of product related not directly accessible process variables and will strongly support the implementation of quality by design in biopharmaceutical production.
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Water related impact of energy: Cost and carbon footprint analysis of water for biopharmaceuticals from tap to waste
Alessandro Luigi Cataldo,Bernhard Sissolak,Karl Metzger,Kristi L. Budzinski,Osamu Shirokizawa,Markus Luchner,Alois Jungbauer,Peter Satzer +7 more
- 01 Nov 2020
TL;DR: In this article, the authors defined a metric, the Water Related Impact of ENergy (WARIEN), to directly correlate the amount of CO2 emitted per kg biopharmaceutical and included membrane-and distillation-based methods for clean water production.
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