https://www.journal-of-hepatology.eu/article/S0168-8278(15)00465-1/pdf

Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance

https://www.gastrojournal.org/article/S0016-5085(11)00273-3/pdf

Coffee Consumption Is Associated With Response to Peginterferon and Ribavirin Therapy in Patients With Chronic Hepatitis C

Aim. The aim of this study was to characterize the genetic profile of patients with chronic hepatitis C virus (HCV) infection relative to polymorphisms rs12979860 and rs8099917 in gene IL28B and the association of those polymorphisms with the response to treatment with pegylated interferon and ribavirin, performed at a reference center in Brazilian Amazonia. Methods. A total of 75 individuals with chronic hepatitis C and 98 healthy individuals from both genders over 18 years old were assessed. DNA samples were collected from leukocytes and subjected to real-time polymerase chain reaction to genotype polymorphisms rs12979860 and rs8099917. Results. Analysis of the allelic and genotypic frequencies of the investigated polymorphisms showed that both groups were in Hardy-Weinberg equilibrium; polymorphism rs12979860 exhibited no significant difference between the groups. For polymorphism rs8099917, allele T was significantly less frequent (P = 0.0195) among the patients (63.3%) than the controls (75.5%), and the patients were 1.7 times as likely to exhibit allele G. No difference in response to treatment was associated with SNP patterns. Conclusion. The results suggest a possible association of SNP rs8099917 with higher odds of chronic HCV infection but do not indicate a putative influence of the investigated SNPs on the sustained virologic response.

/pdf/snp-rs8099917-in-gene-il28b-might-be-associated-with-risk-of-44vsx2vq7i.pdf

SNP rs8099917 in gene IL28B might be associated with risk of chronic infection by HCV but not with response to treatment.

The present invention provides compounds and/or compositions that modulate PP2A methylation and/or activity and methods for preparing the same, which are useful for modulating the demethylation of PP2A, modulating the methylation of PP2 A and/or modulating the activity of PP2A.

Compounds, compositions and methods for making the same

Hepatitis C virus (HCV) infection is the major etiology of chronic liver disease. Polymorphisms in the IL-28B gene region are important in predicting outcome following therapy for chronic hepatitis C virus infection. The aim of this study was to detect the relationship between IL-28B polymorphism and responses to therapy in patients infected with genotype 4. This study included one hundred chronic hepatitis C patients infected with genotype 4, received PEG-IFNα2b plus ribavirin for 24 weeks, as well as, 20 healthy subjects serving as control. Clinical and laboratory parameters, including genetic variation near the IL-28B gene (rs8099917 and rs12979860), were assessed. The results of this study showed significant difference between responders and non-responders as regard SNPs in the interleukin 28B gene at rs8099917 and rs12979860. In rs8099917, TT genotypes had more frequency in responders than GG genotypes. On the other hand, CC genotype in rs12979860 had more frequency in responders than TT genotype. By multiple regression analysis, rs8099917 (TT), total bilirubin, and prothrombin time were independent factors affecting the response to treatment. This results demonstrate that in HCV genotype 4-infected patients, rs12979860 (CC) and rs8099917 (TT) genotypes may identify patients who are likely to respond to treatment. IL-28B SNPs are good predictors of response to combination therapy of HCV.

Is rs8099917 Polymorphism of IL-28B Gene a Good Predictor of Response to Therapy of HCV than rs12979860? An Egyptian Study

CLINICAL ADVANCES IN LIVER, PANCREAS, AND BILIARY TRACT Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

The present invention pertains to the signaling involved in suppression of immune function during hepatitis C infection. More specifically, this invention relates to the discovery that PP2A is involved in the inhibition of interferon alpha signaling in hepatitis C infection. Reduced STAT1 methylation and reduced interferon signaling. Restoring methylation by treatment with a methyl group donor increases interferon signaling.

Treatment of hepatitis c infection by increasing stat1 methylation

75: A variant of IFNλ4 displaying decreased activity is associated with better hepatitis C virus clearance and reduced ISG expression

Due to its increasing prevalence, exceeding 25% of the Western population, non-alcoholic fatty liver disease (NAFLD) merits recognition as one of the most frequent chronic liver diseases (CLD) and requires consideration of the associated disease-related complications and their consequences for the surveillance and treatment of patients and the socio-economy worldwide. Along with the increasing incidence of NAFLD-related cirrhosis and end-stage liver disease, the frequency of NAFLD-related hepatocellular carcinoma (HCC) is rising and expected to surpass HCC related to chronic hepatitis C in the upcoming future. These epidemiologic changes will impact on the overall mortality of CLD and the requirement of organs for transplantation. Although the risk of HCC in NAFLD, similar to other CLD, is related to fibrosis (advanced fibrosis increases the risk of HCC 25-fold), there are reports suggesting a considerable rate of HCC also developing in simple hepatic steatosis. Moreover, HCC is nowadays the leading cause of obesity-related cancer mortality; cancers of other origin such as colorectal cancer are more prevalent in patients with NAFLD and obesity. The pathophysiology of HCC has mainly been studied in models of viral hepatitis. Given the expected raise in NAFLD-related HCC, a better understanding of the pathophysiology of carcinogenesis in NAFLD and obesity is desired in order to better define chemopreventive strategies. Here we review the epidemiology, aetiology, and pathogenesis of HCC on the background of NAFLD and deduce potential consequences for the management of patients in respect to the NAFLD epidemic.

Non-alcoholic fatty liver disease - changing the prevalence of liver cancer?

® ) profitieren. Summary Hepatocellular carcinoma (HCC): screening, diagnosis, and therapy ( HCC is the fifth most common tumour worldwide and the third commonest cause of cancer-related death. ( The incidence of HCC is rising. ( HCC is the leading cause of death in patients with liver cirrhosis. ( HCC can be detected early by monitoring patients with chronic liver disease. ( Surgical resection, liver transplantation and ablative therapies can cure early stage HCC. ( Intermediate and advanced stage HCC are treatable by chemoembolisation and the tyrosine kinase inhibitor sorafenib (Nexavar) respectively.

Hepatozelluläres Karzinom: Screening, Diagnostik und Therapie

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