Markus Geissen
Friedrich Loeffler Institute
9 Papers
98 Citations
Markus Geissen is an academic researcher from Friedrich Loeffler Institute. The author has contributed to research in topics: Scrapie & Parkinson's disease. The author has an hindex of 7, co-authored 9 publications.
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Papers
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
Jens Wagner,Sergey Ryazanov,Sergey Ryazanov,Andrei Leonov,Andrei Leonov,Johannes Levin,Song Shi,Felix Schmidt,Catharina Prix,Francisco J Pan-Montojo,Uwe Bertsch,Gerda Mitteregger-Kretzschmar,Markus Geissen,Martin Eiden,Fabienne Leidel,Thomas Hirschberger,Andreas A. Deeg,Julian J. Krauth,Wolfgang Zinth,Paul Tavan,Jens Pilger,Jens Pilger,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Tobias Frank,Mathias Bähr,Jochen H. Weishaupt,Manfred Uhr,Henning Urlaub,Henning Urlaub,Ulrike Teichmann,Matthias Samwer,Kai Bötzel,Martin H. Groschup,Hans A. Kretzschmar,Christian Griesinger,Christian Griesinger,Armin Giese +38 more
TL;DR: The findings suggest that pathological oligomers in neurodegenerative diseases share structural features, although the main protein component is disease-specific, indicating that compounds such as anle138b that modulate oligomer formation by targeting structure-dependent epitopes can have a broad spectrum of activity in the treatment of different protein aggregation diseases.
385
Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans.
Irina Soltau,E. Mudersbach,Markus Geissen,Edzard Schwedhelm,Martin Sebastian Winkler,Maria Geffken,Sven Peine,Gerhard Schoen,E. Sebastian Debus,Axel Larena-Avellaneda,Guenter Daum +10 more
TL;DR: This study shows that PAD and CS in humans is associated with decreased serum-S1P concentrations and that S1P may possess higher accuracy to indicate these diseases than HDL-C and Receiver operating characteristic curves suggest that S 1P has more power to indicate atherosclerosis (PAD andCS) than high density lipoprotein-cholesterol (HDL-C).
Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins.
Elke Maas,Markus Geissen,Martin H. Groschup,Romina Rost,Takashi Onodera,Hermann M. Schätzl,Ina Vorberg +6 more
TL;DR: It is reported that prion protein knock-out cells can be rendered permissive to scrapie infection by the ectopic expression of PrP, and amino acid polymorphisms located on the outer surfaces of helix 2 and 3 drastically impact conversion efficiency.
42
From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.
Markus Geissen,Fabienne Leidel,Martin Eiden,Thomas Hirschberger,Christine Fast,Uwe Bertsch,Paul Tavan,Armin Giese,Hans A. Kretzschmar,Hermann M. Schätzl,Martin H. Groschup +10 more
TL;DR: A cell‐culture screening system is described that allows for the large‐scale analysis of the PrPres inhibitory potential of a library of compounds and the identification of structural motifs leading potent compounds able to cause PrPres clearance at the cellular level.
25
A Bovine Cell Line That Can Be Infected by Natural Sheep Scrapie Prions
Anja M. Oelschlegel,Anja M. Oelschlegel,Markus Geissen,Matthias Lenk,Roland Riebe,Marlies Angermann,Hermann Schaetzl,Martin H. Groschup +7 more
TL;DR: It is believed that PES cells used together with other prion permissive cell lines will prove a valuable tool for ongoing efforts to understand and defeat prions and prion diseases.