It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

/pdf/disease-drivers-of-aging-2gxdsbteih.pdf

Disease drivers of aging.

Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using 18 FDG PET-CT techniques. Forty-three ischemic stroke patients were randomly divided into 5 groups: the Waiguan (TE5) needling group, the TE5 sham needling group, the sham point needling group, the sham point sham needling group and the non-needling group. Cerebral functional images of all patients were then acquired using PET-CT scans and processed by SPM2 software. Compared with the non-needling group, sham needling at TE5 and needling/sham needling at the sham point did not activate cerebral areas. However, needling at TE5 resulted in the activation of Brodmann Area (BA) 30. Needling/sham needling at TE5 and needling at the sham point did not deactivate any cerebral areas, whereas sham needling at the sham point led to deactivation in BA6. Compared with sham needling at TE5, needling at TE5 activated BA13, 19 and 47 and did not deactivate any areas. Compared with needling at the sham point, needling at TE5 had no associated activation but a deactivating effect on BA9. Needling at TE5 had a regulating effect on cerebral functional areas shown by PET-CT, and this may relate to its impact on the recovery of post-stroke patients.

/pdf/acupuncture-regulates-the-glucose-metabolism-in-cerebral-h89xsg4xy3.pdf

Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients---a PET-CT cerebral functional imaging study

Exploring the aspect of psychosomatics in hypothyroidism: The WOMED model of body–mind interactions based on musculoskeletal changes, psychological stressors, and low levels of magnesium

Transcutaneous Electrical Nerve Stimulation and Acupuncture

Background
A conceptual model of lateral muscular tension in patients presenting thyroid associated ophthalmopathy (TAO) has been recently described Clinical improvement has been achieved by using acupuncture on points belonging to the so-called extraordinary meridians The aim of this study was to characterize the anatomical structures related to these acupuncture points by means of 3D MRI image rendering relying on external markers

/pdf/3d-mri-rendering-of-the-anatomical-structures-related-to-3obuh67oej.pdf

3D-MRI rendering of the anatomical structures related to acupuncture points of the Dai mai, Yin qiao mai and Yang qiao mai meridians within the context of the WOMED concept of lateral tension: implications for musculoskeletal disease.

The concept of acupuncture point localisation in Traditional Chinese Medicine (TCM) is based on millenary practical experience Modern imaging methods such as PET, MRI and SPECT have been used primary for the investigation of the mechanisms of action of acupuncture In this pilot single-case study we have evaluated the technical possibilities for in-vivo imaging of the anatomical relations of acupuncture points using state of the art MRI Preliminary experiments relating to the quality of acupuncture needles under the setting of MRI were done both with stainless steel and gold needles In a second step, in-vivo imaging was carried out A licensed acupuncture practitioner (RM) chose two points belonging to the so-called extraordinary vessels In 2 sequential, separate procedures, he inserted himself gold acupuncture needles using a neutral technique (known as Ping Bu Ping Xie) into the Dai mai and Shen mai points, ie gall bladder 26 and bladder 62 Imaging was done on a Siemens Magnetom Avanto MR scanner using a head array and body coil Mainly T1-weighted imaging sequences, as routinely used for patient exams, were used to obtain multi-slice images In the preliminary experiments only acupuncture needles made of gold showed enough stability in order to be used for further imaging procedures Using an onion and a banana as an object, further studies showed that the gold needles produced a void defect that corresponds to the tip of the inserted needle, while at the same time an artefactually increased diameter was observed The in-vivo experiments showed that the Dai mai point was in relation to the abdominal internal oblique muscle The Shen mai point artefact showed up close to the longus and brevis peroneal tendons at the fibular malleolus Side effects related to heating or burning were not observed Improved anatomical recognition was obtained using 3D-volume rendering techniques Through an adequate choice of acupuncture material (gold needles) as well as of ideal MRI imaging sequences it has been possible to visualize the anatomical characteristics at the acupuncture points Dai mai and Shen mai in-vivo At the selected sites the needles showed a relation to tendino-fascial and muscular structures These anatomical structures fit well into the recently described WOMED concept of lateral tension in which these acupuncture points play a regulatory role

/pdf/in-vivo-visualisation-of-the-anatomical-structures-related-mdkp3ko97l.pdf

In-vivo visualisation of the anatomical structures related to the acupuncture points Dai mai and Shen mai by MRI: A single-case pilot study

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In-vivo visualisation of the anatomical structures related to the acupuncture points Dai mai and Shen mai by MRI: A single-case pilot study