Marko Huotari
University of Eastern Finland
18 Papers
247 Citations
Marko Huotari is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Catechol-O-methyl transferase & Dopamine. The author has an hindex of 11, co-authored 18 publications.
Chat about Author
Papers
Effect of Dopamine Uptake Inhibition on Brain Catecholamine Levels and Locomotion in Catechol-O-methyltransferase-Disrupted Mice
Marko Huotari,Miklós Sántha,Louis R. Lucas,Maria Karayiorgou,Joseph A. Gogos,Pekka T. Männistö +5 more
TL;DR: The role of COMT in dopamine elimination is still minimal in conditions when DAT is inhibited, and attenuation of hyperlocomotion was observed after cocaine treatment in genetic background COMT-deficient male mice.
93
Modulation of histamine H3 receptors in the brain of 6-hydroxydopamine-lesioned rats.
Oleg Anichtchik,Marko Huotari,Nina Peitsaro,John W. Haycock,Pekka T. Männistö,Pertti Panula,Pertti Panula +6 more
TL;DR: The histaminergic system is involved in the pathological process after 6‐OHDA lesion of the rat brain at least through H3 receptor on the later stages of the neurotoxic damage, less H3 receptors became functionally active.
71
d-Amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice
TL;DR: Changes in COMT activity modulates dopamine metabolism but the behavioral effects of d-amphetamine in male mice only to a small extent, and this action does not seem to depend on the actual extracellular dopamine concentration.
65
Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system.
Sulev Kõks,Vallo Volke,Alar Veraksitš,Kertu Rünkorg,Tarvo Sillat,Urho Abramov,Michel Bourin,Marko Huotari,Pekka T. Männistö,Toshimistu Matsui,Eero Vasar +10 more
TL;DR: The targeted mutation of the CCK2 receptor gene induced gene dose-dependent changes in the activity of the dopaminergic system and the density of dopamine D2 receptors was significantly increased in the striatum of homozygous (–/–) animals compared with wild-type (+/+) mice.
47
Tissue histopathology, clinical chemistry and behaviour of adult Comt-gene-disrupted mice.
TL;DR: Owing to the high COMT activities in liver and kidney and the role of COMT in the metabolism of catechol oestrogens, special emphasis was given to the histology of the liver, kidney and oestrogen‐dependent organs such as mammary glands and uterus.
39