Mark Wall
Pennsylvania State University
10 Papers
105 Citations
Mark Wall is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Phosphoribosylaminoimidazolecarboxamide formyltransferase & Chemistry. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Mark Wall include Scripps Research Institute & Johnson & Johnson.
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Papers
Production of cyclic peptides and proteins in vivo.
TL;DR: The ability to generate and screen for backbone cyclic products in vivo is an important milestone toward the goal of generating intracellular cyclic peptide and protein libraries.
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Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH.
Stephen J. Benkovic,Stephen J. Baker,M. R. K. Alley,† Youn-Hi Woo,Yong-Kang Zhang,Tsutomu Akama,Weimin Mao,Justin Baboval,P. T. Ravi Rajagopalan,P. T. Ravi Rajagopalan,Mark Wall,Mark Wall,Lyn Sue Kahng,and Ali Tavassoli,Lucy Shapiro +14 more
TL;DR: A class of boron-containing compounds termed borinic esters that have broad spectrum antibacterial activity with minimum inhibitory concentrations (MIC) in the low microgram/mL range are reported.
116
Human AICAR Transformylase: Role of the 4-Carboxamide of AICAR in Binding and Catalysis†
TL;DR: The results show that the 4-carboxamide of AICAR is essential for catalysis, and it is proposed to assist in mediating proton transfer, catalyzing the reaction by trapping of the addition compound and coupling the unfavorable formation of FAICAR with the highly favorable cyclization reaction.
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Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site.
TL;DR: The homodimeric crystal structure of avian ATIC in complex with the ATIC-specific multisubstrate adduct inhibitor beta-DADF provides a more optimal three-dimensional scaffold to improve the design of specific antineoplastic agents.
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Patent
Dna methyltransferase inhibitors
Stephen J. Benkovic,Lucille Shapiro,Stephen J. Baker,Daphne C. Wahnon,Mark Wall +4 more
- 25 May 2000
TL;DR: In this article, broad-spectrum antibiotics that are inhibitors of bacterial adenine DNA methyltransferases were proposed, and they were shown to be effective in preventing bacterial methyltransferase activation.
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