Mark S. Hill
University of Michigan
11 Papers
23 Citations
Mark S. Hill is an academic researcher from University of Michigan. The author has contributed to research in topics: Evolutionary dynamics & Population. The author has an hindex of 6, co-authored 9 publications. Previous affiliations of Mark S. Hill include University College London.
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Papers
Molecular and evolutionary processes generating variation in gene expression
TL;DR: This integration of molecular and evolutionary biology allows us to understand how the variation in gene expression the authors see today came to be and to predict how it is most likely to evolve in the future.
220
Sexual antagonism exerts evolutionarily persistent genomic constraints on sexual differentiation in Drosophila melanogaster
Mark S. Hill,Filip Ruzicka,Sara Fuentes,Julie M. Collet,Edward H. Morrow,Kevin Fowler,Max Reuter +6 more
TL;DR: The first genome-wide identification and characterisation of sexually antagonistic SNPs in a population of D. melanogaster is reported, providing unprecedented insights into the biology and evolution of sexual antagonism, and open opportunities for more detailed studies of constraints on sex-specific adaptation and mechanisms that resolve them.
Evolving Plastic Responses to External and Genetic Environments.
TL;DR: New research documents this process in a bacterial system and highlights remarkable parallels to the evolution of sexual dimorphism and argues that their approach can aid the understanding of adaptive conflicts between the sexes.
12
Sexual antagonism drives the displacement of polymorphism across gene regulatory cascades.
TL;DR: It is shown that for sites longer than 1 nucleotide, expression polymorphism is maintained only when intermediate expression levels are deleterious to both sexes, and that, in a regulatory cascade,expression polymorphism tends to become displaced over evolutionary time from the target of SA selection to upstream regulators.
11
Genome-wide sexually antagonistic variants reveal longstanding constraints on sexual dimorphism in the fruitfly
Filip Ruzicka,Mark S. Hill,Tanya M. Pennell,Ilona Flis,William P. Gilks,Fiona C. Ingleby,Kevin Fowler,Edward H. Morrow,Max Reuter +8 more
TL;DR: It is proposed that antagonistic variation accumulates due to constraints on the resolution of sexual conflict over protein coding sequences, thus contributing to the long-term maintenance of heritable fitness variation.