Mark R. Prausnitz
Georgia Institute of Technology
424 Papers
6.5K Citations
Mark R. Prausnitz is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Medicine & Transdermal. The author has an hindex of 97, co-authored 392 publications. Previous affiliations of Mark R. Prausnitz include Parker H. Petit Institute for Bioengineering & Bioscience & Procter & Gamble.
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Papers
Transdermal drug delivery
Mark R. Prausnitz,Robert Langer +1 more
TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.
Microneedles for drug and vaccine delivery.
TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
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Current status and future potential of transdermal drug delivery
TL;DR: The already significant impact this field has made on the administration of various pharmaceuticals is discussed; limitations of the current technology are explored; methods under exploration for overcoming these limitations and the challenges ahead are discussed.
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Microneedles for transdermal drug delivery.
TL;DR: Microneedles represent a promising technology to deliver therapeutic compounds into the skin for a range of possible applications and the ratio of microneedle fracture force to skin insertion force was found to be optimal for needles with small tip radius and large wall thickness.
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Microfabricated microneedles: a novel approach to transdermal drug delivery.
TL;DR: These microneedle arrays could be easily inserted into skin without breaking and were shown to increase permeability of human skin in vitro to a model drug, calcein, by up to 4 orders of magnitude.
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