Mark R. Mizee
Netherlands Institute for Neuroscience
21 Papers
12 Citations
Mark R. Mizee is an academic researcher from Netherlands Institute for Neuroscience. The author has contributed to research in topics: Microglia & Multiple sclerosis. The author has an hindex of 12, co-authored 18 publications. Previous affiliations of Mark R. Mizee include VU University Amsterdam & VU University Medical Center.
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Papers
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
Serge A. van de Pavert,Manuela Ferreira,Rita G. Domingues,Hélder Ribeiro,Rosalie Molenaar,Lara Moreira-Santos,Francisca F. Almeida,Sales Ibiza,Inês A. M. Barbosa,Gera Goverse,Carlos Labão-Almeida,Cristina Godinho-Silva,Tanja Konijn,Dennis P. M. Schooneman,Tom O’Toole,Mark R. Mizee,Yasmin Habani,Esther Haak,Fabio R. Santori,Dan R. Littman,Stefan Schulte-Merker,Elaine Dzierzak,J. Pedro Simas,Reina E. Mebius,Henrique Veiga-Fernandes +24 more
TL;DR: A molecular link between maternal nutrients and the formation of immune structures required for resistance to infection in the offspring is revealed and the size of secondary lymphoid organs and the efficiency of immune responses in the adult offspring are established.
Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes
Marlijn van der Poel,Thomas Ulas,Mark R. Mizee,Cheng-Chih Hsiao,Suzanne S. M. Miedema,Adelia,Karianne G. Schuurman,Boy Helder,Sander W. Tas,Joachim L. Schultze,Joachim L. Schultze,Jörg Hamann,Jörg Hamann,Inge Huitinga +13 more
TL;DR: Significant intrinsic differences in the human microglial transcriptome between grey and white matter regions are demonstrated, isolated from MS and non-neurological control donors, and show early microglia changes related to MS pathology.
Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease
Willem Kamphuis,Jinte Middeldorp,Jinte Middeldorp,Lieneke Kooijman,Jacqueline A. Sluijs,Evert-Jan Kooi,Evert-Jan Kooi,Martina Moeton,Michel Freriks,Mark R. Mizee,Mark R. Mizee,Elly M. Hol,Elly M. Hol,Elly M. Hol +13 more
TL;DR: The various GFAP isoforms show differential transcript levels and are upregulated in a concerted manner in AD, with numbers increasing with AD progression, indicating the need for future exploration of underlying mechanisms concerning the functions of GFAPδ and GFAP(+1) isoforms in astrocytes and their possible role in AD pathology.
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Retinoic acid induces blood-brain barrier development.
Mark R. Mizee,D. Wooldrik,Kim Lakeman,B. van het Hof,Joost A. R. Drexhage,Dirk Geerts,Marianna Bugiani,Eleonora Aronica,Reina E. Mebius,Alexandre Prat,H.E. de Vries,Arie Reijerkerk +11 more
TL;DR: Results point to an important role for RA in the induction of the BBB during human and mouse development and in vitro experiments showing RA- and RARβ-dependent induction of different aspects of the brain EC barrier are corroborated.
199
Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions.
Philip G. Nijland,Iliana Michailidou,Maarten E. Witte,Mark R. Mizee,Susanne M. A. van der Pol,Bert van het Hof,Arie Reijerkerk,Luc Pellerin,Paul van der Valk,Helga E. de Vries,Jack van Horssen +10 more
TL;DR: An altered expression of these nutrient transporters in MS brain tissue is demonstrated, including a marked reduction of axonal GLUT3 and MCT2 expression in chronic lesions, which may impede efficient nutrient supply to the hypoxic demyelinated axons thereby contributing to the ongoing neurodegeneration in MS.
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