38 Papers
181 Citations
Mark Pulse is an academic researcher from University of North Texas Health Science Center. The author has contributed to research in topics: Clostridium difficile & Medicine. The author has an hindex of 12, co-authored 31 publications. Previous affiliations of Mark Pulse include University of North Texas System.
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Papers
Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?
Steven H. Marshall,Andrea M. Hujer,Andrea M. Hujer,Laura J. Rojas,Laura J. Rojas,Krisztina M. Papp-Wallace,Romney M. Humphries,Brad Spellberg,Kristine M. Hujer,Kristine M. Hujer,Emma K. Marshall,Susan D. Rudin,Susan D. Rudin,Federico Perez,Federico Perez,Brigid Wilson,Ronald B. Wasserman,Linda Chikowski,David L. Paterson,Alejandro J. Vila,David van Duin,Barry N. Kreiswirth,Henry F. Chambers,Vance G. Fowler,Michael R. Jacobs,Mark Pulse,William J. Weiss,Robert A. Bonomo +27 more
TL;DR: In vitro activity of CAZ-AVI in combination with ATM against diverse Enterobacteriaceae possessing MBLs was demonstrated, and the data presented herein require us to carefully consider this new therapeutic combination to treat infections caused by MBL-producing Enterobacteria.
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Evaluation of Ceftazidime and NXL104 in Two Murine Models of Infection Due to KPC-Producing Klebsiella pneumoniae
Andrea Endimiani,Kristine M. Hujer,Kristine M. Hujer,Andrea M. Hujer,Andrea M. Hujer,Mark Pulse,William J. Weiss,Robert A. Bonomo,Robert A. Bonomo +8 more
TL;DR: Despite resistance to CAZ and possessing a complex β-lactamase background, NXL104 combined with CAZ proved to be very effective in murine models of infection due to contemporary highly resistant KPC-producing K. pneumoniae isolates.
78
Stress-induced differences in primary and secondary resistance against bacterial sepsis corresponds with diverse corticotropin releasing hormone receptor expression by pulmonary CD11c+ MHC II+ and CD11c- MHC II+ APCs.
TL;DR: It is concluded that repeated restraint stress has distinct influences on immune cell populations that appear to be important in the generation of innate and adaptive immune responses along the respiratory tract with the potential to influence local and systemic protection against disease pathogenesis.
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Simultaneous determination of rifampicin and levofloxacin concentrations in catheter segments from a mouse model of a device-related infection by liquid chromatography/electrospray ionization tandem mass spectrometry.
TL;DR: The HPLC-MS assay uses less tissue than previously described methods and can be applied to determine the penetration of rifampicin and the fluoroquinolone in catheter segments from a mouse model of a device-related infection.
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Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes.
Robert E. Lee Trout,Allison L. Zulli,Eugen F. Mesaros,Randy W. Jackson,Boyd Steven A,Bin Liu,Jodie Hamrick,Denis M. Daigle,Cassandra L Chatwin,Kaitlyn John,Lisa McLaughlin,Susan M Cusick,William J. Weiss,Mark Pulse,Daniel C. Pevear,Greg Moeck,Luigi Xerri,Christopher J. Burns +17 more
TL;DR: In this paper, an iterative program combining medicinal chemistry, biochemical testing, microbiological profiling, and evaluation of oral pharmacokinetics was initiated to address the lack of outpatient treatment, which resulted in increases in costly hospital Emergency Department (ED) visits and hospitalizations due to the requirement for parenteral antibiotic therapy for infections caused by difficult-to-treat bacteria.
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