Mark Ptashne
Memorial Sloan Kettering Cancer Center
10 Papers
4 Citations
Mark Ptashne is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Nucleosome & Enhancer. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Mark Ptashne include Kettering University.
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Papers
A RSC/Nucleosome Complex Determines Chromatin Architecture and Facilitates Activator Binding
Monique Floer,Xin Wang,Vidya Prabhu,Georgina Berrozpe,Santosh Narayan,Dan Spagna,David Alvarez,Jude Kendall,Alexander Krasnitz,Asya Stepansky,James W. Hicks,Gene O. Bryant,Mark Ptashne +12 more
TL;DR: The results show that both prior to and following induction, specific DNA-binding proteins are the predominant determinants of chromatin architecture at the GAL1/10 genes.
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OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts.
TL;DR: It is shown that, like OCT4, SOX2 functions as a transcriptional activator, and this results are consistent with the idea that, during reprogramming, there is an intermediate state that is distinct from both parental cells and iPSCs.
Nucleosome Avidities and Transcriptional Silencing in Yeast
TL;DR: The quantitative nucleosome occupancy assay is used to show that Sirs (which bind nucleosomes) increase the avidities with which thoseucleosomes form at the promoters, which can account for at least part of the repressive effects of the Sirs and can explain why silencing is effective in countering weak activation only.
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Regulation of a Mammalian Gene Bearing a CpG Island Promoter and a Distal Enhancer
TL;DR: Rules for nucleosome disposition in yeast are shown to apply to the control of Kit, a mammalian gene, and the inhibitory effects of nucleosomes facilitate high factors of induction by mammalian activators working in the absence of specific repressors.
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Francois Jacob 1920–2013
TL;DR: For instance, this paper wrote that "Hardly a week has gone by without my asking him what he would think of this or that result, this or this sentence in a paper, and so on." And so on hearing of his death at 92 in Paris, I began to ponder again the source of his powers that were magnetic.
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