Mark O. Goodarzi
Cedars-Sinai Medical Center
317 Papers
2.8K Citations
Mark O. Goodarzi is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Insulin resistance & Medicine. The author has an hindex of 65, co-authored 245 publications. Previous affiliations of Mark O. Goodarzi include Broad Institute & University of California, Los Angeles.
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Papers
The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial.
Saeid Doaei,Saeid Doaei,Somayeh Gholami,Samira Rastgoo,Maryam Gholamalizadeh,Fatemeh Bourbour,Seyedeh Elaheh Bagheri,Forough Samipoor,Mohammad Esmail Akbari,Mahdi Shadnoush,Fereshteh Ghorat,Seyed Alireza Mosavi Jarrahi,Narjes Ashouri Mirsadeghi,Azadeh Hajipour,Parvin Joola,Alireza Moslem,Mark O. Goodarzi +16 more
TL;DR: Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections as discussed by the authors, and the effect of Omega-3 supplementation on inflammatory and biochemical markers in critically ill patients with COVID-19 was examined.
Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys.
Ning Xu,Soonil Kwon,David H. Abbott,David H. Geller,Daniel A. Dumesic,Daniel A. Dumesic,Ricardo Azziz,Xiuqing Guo,Mark O. Goodarzi +8 more
TL;DR: This pilot study suggests that excess fetal androgen exposure in female nonhuman primates may predispose to PCOS via alteration of the epigenome, providing a novel avenue to understand PCOS in humans.
CRTC3 links catecholamine signalling to energy balance
Youngsup Song,Judith Y. Altarejos,Mark O. Goodarzi,Hiroshi Inoue,Xiuqing Guo,Rebecca Berdeaux,Jeong-Ho Kim,Jason Goode,Motoyuki Igata,José C. Paz,Meghan F. Hogan,Pankaj K. Singh,Naomi Goebel,Lili Vera,Nina Miller,Jinrui Cui,Matthew Jones,Yii-Der Ida Chen,Kent D. Taylor,Willa A. Hsueh,Jerome I. Rotter,Marc Montminy +21 more
TL;DR: It is shown that the cAMP response element binding (CREB) coactivator Crtc3 promotes obesity by attenuating β-adrenergic receptor signalling in adipose tissue by upregulating the expression of Rgs2, a GTPase-activating protein that also inhibits adenyl cyclase activity.
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Aldi T. Kraja,Chunyu Liu,Jessica L. Fetterman,Mariaelisa Graff,Christian Theil Have,Charles Gu,Lisa R. Yanek,Mary F. Feitosa,Dan E. Arking,Daniel I. Chasman,Kristin L. Young,Symen Ligthart,W. David Hill,Stefan Weiss,Jian'an Luan,Franco Giulianini,Ruifang Li-Gao,Fernando Pires Hartwig,Fernando Pires Hartwig,Shiow J. Lin,Lihua Wang,Tom G. Richardson,Jie Yao,Eliana Portilla Fernández,Mohsen Ghanbari,Mary K. Wojczynski,Wen Jane Lee,Maria Argos,Sebastian M. Armasu,Ruteja A. Barve,Kathleen A. Ryan,Ping An,Thomas J. Baranski,Suzette J. Bielinski,Donald W. Bowden,Ulrich Broeckel,Kaare Christensen,Audrey Y. Chu,Janie Corley,Simon R. Cox,André G. Uitterlinden,Fernando Rivadeneira,Cheryl D. Cropp,E. Warwick Daw,Diana van Heemst,Lisa de las Fuentes,He Gao,Ioanna Tzoulaki,Ioanna Tzoulaki,Tarunveer S. Ahluwalia,Renée de Mutsert,Leslie S. Emery,A. Mesut Erzurumluoglu,James A. Perry,Mao Fu,Nita G. Forouhi,Zhenglong Gu,Yang Hai,Sarah E. Harris,Gibran Hemani,Steven C. Hunt,Marguerite R. Irvin,Anna Jonsson,Anne E. Justice,Nicola D. Kerrison,Nicholas B. Larson,Keng Hung Lin,Latisha Love-Gregory,Rasika A. Mathias,Joseph H. Lee,Matthias Nauck,Raymond Noordam,Ken K. Ong,James S. Pankow,Amit Patki,Alison Pattie,Astrid Petersmann,Qibin Qi,Rasmus Ribel-Madsen,Rebecca Rohde,Kevin Sandow,Theresia M. Schnurr,Tamar Sofer,Tamar Sofer,John M. Starr,Adele M. Taylor,Alexander Teumer,Nicholas J. Timpson,Hugoline G. de Haan,Yujie Wang,Peter Weeke,Christine Williams,Hongsheng Wu,Wei Yang,Donglin Zeng,Daniel R. Witte,Bruce S. Weir,Nicholas J. Wareham,Henrik Vestergaard,Henrik Vestergaard,Stephen Turner,Christian Torp-Pedersen,Evie Stergiakouli,Wayne Huey-Herng Sheu,Frits R. Rosendaal,M. Arfan Ikram,Oscar H. Franco,Oscar H. Franco,Paul M. Ridker,Thomas T. Perls,Oluf Pedersen,Ellen A. Nohr,Anne B. Newman,Allan Linneberg,Claudia Langenberg,Tuomas O. Kilpeläinen,Sharon L.R. Kardia,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Thorkild I. A. Sørensen,Georg Homuth,Torben Hansen,Mark O. Goodarzi,Ian J. Deary,Cramer Christensen,Yii-Der Ida Chen,Aravinda Chakravarti,Ivan Brandslund,Klaus Bønnelykke,Kent D. Taylor,James G. Wilson,Santiago Rodriguez,Gail Davies,Bernardo L. Horta,Bharat Thyagarajan,Dabeeru C. Rao,Niels Grarup,Victor G. Davila-Roman,Gavin Hudson,Xiuqing Guo,Donna K. Arnett,Caroline Hayward,Dhananjay Vaidya,Dennis O. Mook-Kanamori,Hemant K. Tiwari,Daniel Levy,Ruth J. F. Loos,Abbas Dehghan,Paul Elliott,Afshan N. Malik,Robert A. Scott,Diane M. Becker,Mariza de Andrade,Michael A. Province,James B. Meigs,James B. Meigs,Jerome I. Rotter,Kari E. North +158 more
TL;DR: The results suggest that mtDNA and MT-nDNA genes and variants reported make important contributions to glucose and insulin metabolism, adipocyte regulation, diabetes, and cardiovascular disease.
Associations of autozygosity with a broad range of human phenotypes
David W. Clark,Yukinori Okada,Kristjan H. S. Moore,Dan Mason,Nicola Pirastu,Ilaria Gandin,Ilaria Gandin,Hannele Mattsson,Hannele Mattsson,Catriona L. K. Barnes,Kuang Lin,Jing Hua Zhao,Patrick Deelen,Rebecca Rohde,Claudia Schurmann,Xiuqing Guo,Franco Giulianini,Weihua Zhang,Weihua Zhang,Carolina Medina-Gomez,Robert Karlsson,Yanchun Bao,Traci M. Bartz,Clemens Baumbach,Ginevra Biino,Matthew J. Bixley,Marco Brumat,Jin-Fang Chai,Tanguy Corre,Tanguy Corre,Diana L. Cousminer,Annelot M. Dekker,David Eccles,David Eccles,Kristel R van Eijk,Christian Fuchsberger,He Gao,Marine Germain,Marine Germain,Scott D. Gordon,Hugoline G. de Haan,Sarah E. Harris,Edith Hofer,Alicia Huerta-Chagoya,Catherine Igartua,Iris E. Jansen,Iris E. Jansen,Yucheng Jia,Tim Kacprowski,Tim Kacprowski,Torgny Karlsson,Marcus E. Kleber,Shengchao Alfred Li,Ruifang Li-Gao,Anubha Mahajan,Koichi Matsuda,Karina Meidtner,Weihua Meng,May E. Montasser,Peter J. van der Most,Matthias Munz,Teresa Nutile,Teemu Palviainen,Gauri Prasad,Rashmi B. Prasad,Tallapragada Divya Sri Priyanka,Federica Rizzi,Erika Salvi,Erika Salvi,Bishwa Raj Sapkota,Daniel Shriner,Line Skotte,Melissa C. Smart,Albert V. Smith,Ashley van der Spek,Cassandra N. Spracklen,Rona J. Strawbridge,Rona J. Strawbridge,Salman M. Tajuddin,Stella Trompet,Constance Turman,Niek Verweij,Clara Viberti,Lihua Wang,Helen R. Warren,Robyn E Wootton,Lisa R. Yanek,Jie Yao,Noha A. Yousri,Noha A. Yousri,Wei Zhao,Adebowale Adeyemo,Saima Afaq,Carlos A. Aguilar-Salinas,Masato Akiyama,Matthew L. Albert,Matthew A. Allison,Maris Alver,Tin Aung,Fereidoun Azizi,Amy R. Bentley,Heiner Boeing,Eric Boerwinkle,Judith B. Borja,Gert J. de Borst,Erwin P. Bottinger,Erwin P. Bottinger,Linda Broer,Harry Campbell,Stephen J. Chanock,Miao-Li Chee,Guanjie Chen,Yii-Der Ida Chen,Zhengming Chen,Yen-Feng Chiu,Massimiliano Cocca,Francis S. Collins,Maria Pina Concas,Janie Corley,Giovanni Cugliari,Rob M. van Dam,Rob M. van Dam,Anna Damulina,Maryam S. Daneshpour,Felix R. Day,Graciela E. Delgado,Klodian Dhana,Klodian Dhana,Klodian Dhana,Alex S. F. Doney,Marcus Dörr,Ayo P. Doumatey,Nduna Dzimiri,S. Sunna Ebenesersdóttir,S. Sunna Ebenesersdóttir,Joshua Elliott,Paul Elliott,Ralf Ewert,Janine F. Felix,Krista Fischer,Barry I. Freedman,Giorgia Girotto,Anuj Goel,Martin Gögele,Mark O. Goodarzi,Mariaelisa Graff,Einat Granot-Hershkovitz,Francine Grodstein,Simonetta Guarrera,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Kamran Guity,Bjarni Gunnarsson,Yu Guo,Saskia P. Hagenaars,Saskia P. Hagenaars,Christopher A. Haiman,Avner Halevy,Tamara B. Harris,Mehdi Hedayati,David A. van Heel,Makoto Hirata,Imo Hofer,Chao A. Hsiung,Jinyan Huang,Yi-Jen Hung,Yi-Jen Hung,M. Arfan Ikram,Anuradha Jagadeesan,Anuradha Jagadeesan,Pekka Jousilahti,Yoichiro Kamatani,Masahiro Kanai,Masahiro Kanai,Nicola D. Kerrison,Thorsten Kessler,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Dominique P.V. de Kleijn,Woon-Puay Koh,Ivana Kolcic,Peter Kraft,Bernhard K. Krämer,Zoltán Kutalik,Zoltán Kutalik,Johanna Kuusisto,Claudia Langenberg,Lenore J. Launer,Debbie A Lawlor,I-Te Lee,I-Te Lee,Wen-Jane Lee,Markus M. Lerch,Liming Li,Jianjun Liu,Jianjun Liu,Marie Loh,Marie Loh,Marie Loh,Stephanie J. London,Stephanie J. Loomis,Yingchang Lu,Jian'an Luan,Reedik Mägi,Ani Manichaikul,Paolo Manunta,Gisli Masson,Nana Matoba,Xue W. Mei,Christa Meisinger,Thomas Meitinger,Massimo Mezzavilla,Lili Milani,Iona Y Millwood,Yukihide Momozawa,Amy Moore,Pierre-Emmanuel Morange,Hortensia Moreno-Macías,Trevor A. Mori,Alanna C. Morrison,Taulant Muka,Taulant Muka,Yoshinori Murakami,Alison D. Murray,Renée de Mutsert,Josyf C. Mychaleckyj,Mike A. Nalls,Matthias Nauck,Matt J. Neville,Matt J. Neville,Ilja M. Nolte,Ken K. Ong,Lorena Orozco,Sandosh Padmanabhan,Gunnar K. Pálsson,James S. Pankow,Cristian Pattaro,Alison Pattie,Ozren Polasek,Neil Poulter,Peter P. Pramstaller,Lluis Quintana-Murci,Lluis Quintana-Murci,Katri Räikkönen,Sarju Ralhan,Dabeeru C. Rao,Wouter van Rheenen,Stephen S. Rich,Paul M. Ridker,Paul M. Ridker,Cornelius A. Rietveld,Antonietta Robino,Frank J. A. van Rooij,Daniela Ruggiero,Yasaman Saba,Charumathi Sabanayagam,Maria Sabater-Lleal,Cinzia Sala,Veikko Salomaa,Kevin Sandow,Helena Schmidt,Laura J. Scott,William R. Scott,Bahareh Sedaghati-khayat,Bengt Sennblad,Bengt Sennblad,Jessica van Setten,Peter S. Sever,Wayne Huey-Herng Sheu,Yuan Shi,Smeeta Shrestha,Smeeta Shrestha,Sharvari Rahul Shukla,Jon K. Sigurdsson,Timo Tõnis Sikka,Jai Rup Singh,Blair H. Smith,Alena Stančáková,Alice Stanton,John M. Starr,Lilja Stefansdottir,Leon Straker,Patrick Sulem,Gardar Sveinbjornsson,Morris A. Swertz,Adele M. Taylor,Kent D. Taylor,Natalie Terzikhan,Natalie Terzikhan,Yih Chung Tham,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Annika Tillander,Russell P. Tracy,Teresa Tusié-Luna,Ioanna Tzoulaki,Ioanna Tzoulaki,Simona Vaccargiu,Jagadish Vangipurapu,Jan H. Veldink,Veronique Vitart,Uwe Völker,Eero Vuoksimaa,Salma M. Wakil,Melanie Waldenberger,Gurpreet Singh Wander,Ya Xing Wang,Nicholas J. Wareham,Sarah H. Wild,Chittaranjan S. Yajnik,Jian-Min Yuan,Lingyao Zeng,Liang Zhang,Jie Zhou,Najaf Amin,Folkert W. Asselbergs,Stephan J. L. Bakker,Diane M. Becker,Benjamin Lehne,David A. Bennett,Leonard H. van den Berg,Sonja I. Berndt,Dwaipayan Bharadwaj,Lawrence F. Bielak,Murielle Bochud,Michael Boehnke,Claude Bouchard,Jonathan P. Bradfield,Jennifer A. Brody,Archie Campbell,Shai Carmi,Mark J. Caulfield,David Cesarini,John C. Chambers,Giriraj R. Chandak,Ching-Yu Cheng,Marina Ciullo,Marilyn C. Cornelis,Daniele Cusi,Daniele Cusi,George Davey Smith,Ian J. Deary,Rajkumar Dorajoo,Cornelia M. van Duijn,Cornelia M. van Duijn,David Ellinghaus,Jeanette Erdmann,Johan G. Eriksson,Evangelos Evangelou,Evangelos Evangelou,Michele K. Evans,Jessica D. Faul,Bjarke Feenstra,Mary F. Feitosa,Sylvain Foisy,Andre Franke,Yechiel Friedlander,Paolo Gasparini,Christian Gieger,Clicerio Gonzalez,Philippe Goyette,Struan F.A. Grant,Lyn R. Griffiths,Leif Groop,Leif Groop,Vilmundur Gudnason,Ulf Gyllensten,Hakon Hakonarson,Anders Hamsten,Pim van der Harst,Chew-Kiat Heng,Chew-Kiat Heng,Andrew A. Hicks,Hagit Hochner,Heikki V. Huikuri,Steven C. Hunt,Steven C. Hunt,Vincent W. V. Jaddoe,Philip L. De Jager,Philip L. De Jager,Magnus Johannesson,Åsa Johansson,Jost B. Jonas,Jost B. Jonas,J. Wouter Jukema,Juhani Junttila,Jaakko Kaprio,Sharon L.R. Kardia,Fredrik Karpe,Fredrik Karpe,Meena Kumari,Markku Laakso,Sander W. van der Laan,Jari Lahti,Matthias Laudes,Rodney A. Lea,Wolfgang Lieb,Thomas Lumley,Nicholas G. Martin,Winfried März,Winfried März,Giuseppe Matullo,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Sarah E. Medland,Tony R. Merriman,Andres Metspalu,Brian F. Meyer,Karen L. Mohlke,Grant W. Montgomery,Grant W. Montgomery,Dennis O. Mook-Kanamori,Patricia B. Munroe,Kari E. North,Dale R. Nyholt,Dale R. Nyholt,Jeffery R. O'Connell,Carole Ober,Albertine J. Oldehinkel,Walter Palmas,Colin N. A. Palmer,Gerard Pasterkamp,Etienne Patin,Etienne Patin,Craig E. Pennell,Craig E. Pennell,Louis Pérusse,Patricia A. Peyser,Mario Pirastu,Tinca J. C. Polderman,David J. Porteous,Danielle Posthuma,Bruce M. Psaty,Bruce M. Psaty,John D. Rioux,John D. Rioux,Fernando Rivadeneira,Charles N. Rotimi,Jerome I. Rotter,Igor Rudan,Hester M. den Ruijter,Dharambir K. Sanghera,Naveed Sattar,Reinhold Schmidt,Matthias B. Schulze,Heribert Schunkert,Robert A. Scott,Alan R. Shuldiner,Alan R. Shuldiner,Xueling Sim,Neil Small,Jennifer A. Smith,Nona Sotoodehnia,E-Shyong Tai,Alexander Teumer,Nicholas J. Timpson,Daniela Toniolo,David-Alexandre Trégouët,Tiinamaija Tuomi,Peter Vollenweider,Carol A. Wang,Carol A. Wang,David R. Weir,John Whitfield,Cisca Wijmenga,Tien Yin Wong,John Wright,Jingyun Yang,Lei Yu,Babette S. Zemel,Alan B. Zonderman,Markus Perola,Patrik K. E. Magnusson,André G. Uitterlinden,Jaspal S. Kooner,Daniel I. Chasman,Daniel I. Chasman,Ruth J. F. Loos,Ruth J. F. Loos,Nora Franceschini,Lude Franke,Chris Haley,Caroline Hayward,Robin G. Walters,John R. B. Perry,T Esko,T Esko,Agnar Helgason,Agnar Helgason,Kari Stefansson,Kari Stefansson,Peter K. Joshi,Michiaki Kubo,James F. Wilson +496 more
TL;DR: In this paper, the authors used genomic inbreeding coefficients (FROH) for >1.4 million individuals and found that FROH is significantly associated with apparently deleterious changes in 32 out of 100 traits analysed.