Mark Nickerson
University of Manitoba
15 Papers
326 Citations
Mark Nickerson is an academic researcher from University of Manitoba. The author has contributed to research in topics: Shock (circulatory) & Epinephrine. The author has an hindex of 10, co-authored 15 publications.
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Papers
Receptor Occupancy and Tissue Response
TL;DR: Basic formulations applying mass-action considerations to the differentiation of types of inhibition are those of Gaddum, applied largely to tissue and organ responses, and of Linweaver and Burke, which have been applied both to relatively simple enzyme systems and to complex responses of tissues and of intact animals.
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Effect of ambient temperature on thermal responses to drugs.
Irving Shemano,Mark Nickerson +1 more
TL;DR: Thermal responses to a variety of drugs have been investigated at various ambient temperatures, using unanesthetized rats, either lightly restrained or paralyzed with tubocurarine, suggesting that ambient temperature is a major factor determining thermal responses to many drugs.
Cardiac Arrhythmias Induced by Minimal Doses of Epinephrine in Cyclopropane-Anesthetized Dogs
TL;DR: Dichloroisoproterenol appears to attenuate the induction of bigeminy by epinephrine to a considerably lesser extent than the major arrhythmias expected on injection of large doses of this sympathomimetic.
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Pathogenesis of "Electrolyte-Steroid-Cardiopathy"
TL;DR: It is concluded that the “electro lyte-steroid-cardiopathy” results from a simple intracellular potassium deficiency and its sequelae, and that the roles of the steroid-cathartic electrolyte, and other agents and procedures are to induce potassium depletion by various mechanisms.
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