Mark Munson
University of Minnesota
34 Papers
629 Citations
Mark Munson is an academic researcher from University of Minnesota. The author has contributed to research in topics: Solid-phase synthesis & Peptide synthesis. The author has an hindex of 11, co-authored 34 publications. Previous affiliations of Mark Munson include University of Barcelona & Amgen.
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Papers
Patent
P38 inhibitors and methods of use thereof
Mark Munson,David A. Mareska,Youngboo Kim,Robert D. Groneberg,James P. Rizzi,Martha Rodriguez,Ganghyeok Kim,Guy Vigers,Chang Rao,Devan Balachari,Darren Harvey +10 more
- 25 Feb 2004
TL;DR: In this article, an invention related to inhibitors of p38, and methods for producing these inhibitors are described. And pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by p38 are provided.
326
Cyclization of disulfide-containing peptides in solid-phase synthesis.
Fernando Albericio,Robert P. Hammer,C. Garcia‐Echeverria,M. A. Molins,Jane Chang,Mark Munson,Miquel Pons,Ernest Giralt,George Barany +8 more
TL;DR: Assemblies of linear sequences proceeded smoothly, and polymer-supported oxidations were carried out in a variety of ways either directly or after deblocking to the resin-bound dithiol, and overall yields were as high as 60-90%.
101
Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers
Malvika Koundinya,Judith Sudhalter,Albane Courjaud,Bruno Lionne,Gaetan Touyer,Luc Bonnet,Isabelle Menguy,Isabelle Schreiber,Christelle Perrault,Stephanie Vougier,Brigitte Benhamou,Bailin Zhang,Timothy He,Qiang Gao,Patricia Gee,Daniel Simard,M. Paola Castaldi,Ronald Tomlinson,Stephan Reiling,Matthieu Barrague,Richard Newcombe,Hui Cao,Yanjun Wang,Fangxian Sun,Joshua Murtie,Mark Munson,Eric Yang,David Harper,Monsif Bouaboula,Jack Pollard,Claudine Grepin,Carlos Garcia-Echeverria,Hong Cheng,Francisco Adrian,Christopher Winter,Stuart Licht,Ivan Cornella-Taracido,Rosalia Arrebola,Aaron J. Morris +38 more
TL;DR: A high-throughput synthetic lethal screen for small molecules that selectively inhibit the growth of KRAS mutant cell lines in soft agar is reported, identifying the target of the most KRAS-selective chemical series as dihydroorotate dehydrogenase (DHODH).
99
Synthesis of α-conotoxin SI, a bicyclic tridecapeptide amide with two disulfide bridges : illustration of novel protection schemes and oxidation strategies
Mark Munson,George Barany +1 more
TL;DR: In this article, the synthesis of α-conotoxin SI, a tridecapeptide amide of sequence H-Ile-Cys,Cys-Asn-Pro-Ala-CYS-Gly-pro-Lys-Tyr-Ser-Ser Cys-NH 2, with bicyclic disulfides connecting Cys 2 with Cys 7 and Cys 3 with cys 13, was described.
64
Patent
Triazolopyridine compounds as pim kinase inhibitors
Shelley Allen,Celeste Laura L,T. Gregg Davis,Robert Kirk Delisle,Julie Marie Greschuk,Stefan Gross,Erik James Hicken,Leila J. Jackson,Joseph P. Lyssikatos,Nicholas C. Kallan,Marmsater Fredrik P,Mark Munson,Pheneger Jed,Bryson Rast,Robinson John E,Stephen T. Schlachter,George T. Topalov,A. Dale Wright,Qian Zhao +18 more
- 18 Aug 2009
TL;DR: In this article, the compounds of Formula (I) are defined as receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.
64