Mark Mellinger
DuPont
17 Papers
162 Citations
Mark Mellinger is an academic researcher from DuPont. The author has contributed to research in topics: TosMIC & Intramolecular force. The author has an hindex of 7, co-authored 17 publications.
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Papers
An investigation of imidazole and oxazole syntheses using aryl-substituted TosMIC reagents.
TL;DR: Efficient and mild protocols for preparing polysubstituted imidazoles in a single pot from aryl-subst ituted tosylmethyl isocyanide (TosMIC) reagents and imines generated in situ are described.
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An efficient method for the synthesis of substituted TosMIC precursors
TL;DR: In this paper, a high-yielding method for the synthesis of substituted tosylmethyl formamides, which are readily converted to the corresponding isocyanides, is described.
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Novel syntheses of camptothecin alkaloids, part I. Intramolecular [4+2] cycloadditions of N-arylimidates and 4H-3,1-benzoxazin-4-ones as 2-aza-1,3-dienes
Joseph M. Fortunak,Mastrocola Antonietta Rose,Mark Mellinger,Nicolas J Sisti,Jeffery Lee Wood,Zhi-Ping Zhuang +5 more
TL;DR: The first reported intramolecular cycloadditions of both N-arylimidates and 4 H -3,1-benzoxazin-4-ones acting as 2-aza-1,3-dienes are described in this paper.
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Novel syntheses of camptothecin alkaloids, part 2. concise synthesis of (S)-camptothecins
Joseph M. Fortunak,John Kitteringham,Mastrocola Antonietta Rose,Mark Mellinger,Nicholas Sisti,Jeffery Lee Wood,Zhi-Ping Zhuang +6 more
TL;DR: In this paper, a 9-step convergent total synthesis of (S )-camptothecin alkaloids is described, where the intramolecular cycloaddition of an N-arylimidate with an alkyne is used to prepare the ABC ring system.
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Preparation of mappicine ketones from camptothecins: Chemistry of the camptothecin E ring
TL;DR: Camptothecin and its analogs are thermolyzed at 150-200 °C to yield mappicine ketone derivatives by loss of carbon dioxide from the α-hydroxylactone as discussed by the authors.
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