Mark Lunzer
University of Minnesota
15 Papers
56 Citations
Mark Lunzer is an academic researcher from University of Minnesota. The author has contributed to research in topics: Molecular evolution & Chemistry. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Mark Lunzer include Biotechnology Institute.
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Papers
Pervasive cryptic epistasis in molecular evolution
TL;DR: It is shown that epistatic interactions can occur between distant (>20Å) sites, and Phylogenetic analysis shows that incompatible mutations were fixed in different lineages.
Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases.
Titu Devamani,Alissa Rauwerdink,Mark Lunzer,Bryan J. Jones,Joanna L. Mooney,Maxilmilien Alaric O Tan,Zhi-Jun Zhang,Jian-He Xu,Antony M. Dean,Antony M. Dean,Romas J. Kazlauskas +10 more
TL;DR: One ancestral enzyme along the path from esterase to hydroxynitrile lyases was especially promiscuous and catalyzed both hydrolysis and lyase reactions with many substrates, but HNL1 is especially so.
Enzyme Kinetics, Substitutable Resources and Competition: From Biochemistry to Frequency-Dependent Selection in lac
TL;DR: It is shown that differential resource utilization during competition for mixtures of galactosides produces frequency-dependent selection at lac, and a comparison of predictions, based on first principles, with experimental outcomes reveals an additional, unanticipated source of weak selection.
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Evolution of a Catalytic Mechanism
Alissa Rauwerdink,Mark Lunzer,Titu Devamani,Bryan J. Jones,Joanna L. Mooney,Zhi-Jun Zhang,Jian-He Xu,Romas J. Kazlauskas,Antony M. Dean +8 more
TL;DR: It is shown that resurrected ancestral plant esters are as catalytically specific as modern esterases, that the ancestor of modern acetone cyanohydrin lyases was itself only very weakly promiscuous, and that improvements in lyase activity came at the expense of esterase activity, supporting the innovation-amplification-divergence hypothesis.