Mark J. Hickey
Seattle Biomed
25 Papers
637 Citations
Mark J. Hickey is an academic researcher from Seattle Biomed. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 22, co-authored 25 publications. Previous affiliations of Mark J. Hickey include United States Department of Veterans Affairs & University of Washington.
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Papers
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis.
TL;DR: The live attenuated bacillus Calmette-Guerin (BCG) vaccine for the prevention of disease associated with mycobacterium tuberculosis was derived from the closely related virulent tubercle bacilli, Mycobacteriaium bovis, and the precise junctions and DNA sequence of each deletion were determined as discussed by the authors.
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Deletion of RD1 from Mycobacterium tuberculosis Mimics Bacille Calmette-Guérin Attenuation
Kaeryn N. Lewis,Reiling Liao,Kristi M. Guinn,Mark J. Hickey,Sherilyn Smith,Marcel A. Behr,David R. Sherman +6 more
TL;DR: It was concluded that genes within or controlled by RD1 are essential for MTB virulence and that loss of RD1 was important in BCG attenuation.
Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis
Kristi M. Guinn,Mark J. Hickey,Sanjeev K. Mathur,Kelly L. Zakel,Jeff E. Grotzke,David M. Lewinsohn,Sherilyn Smith,David R. Sherman +7 more
TL;DR: The results indicate that RD1 genes work together to form a single virulence determinant, and argue thatRD1 encodes a novel specialized secretion system that is required for pathogenesis of MTB.
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The Mycobacterium tuberculosis regulatory network and hypoxia.
James E. Galagan,Kyle J. Minch,Matthew W. Peterson,Anna Lyubetskaya,Elham Azizi,Linsday Sweet,Antonio L.C. Gomes,Tige R. Rustad,Gregory Dolganov,Irina Glotova,Thomas Abeel,Thomas Abeel,Chris Mahwinney,Adam D. Kennedy,Rene Allard,William Brabant,Andrew S Krueger,Suma Jaini,Brent Honda,Wen-Han Yu,Mark J. Hickey,Jeremy Zucker,Christopher D. Garay,Brian Weiner,Peter Sisk,Christian Stolte,Jessica K. Winkler,Yves Van de Peer,Paul Iazzetti,Diogo M. Camacho,Jonathan M. Dreyfuss,Yang Liu,Anca Dorhoi,Hans-Joachim Mollenkopf,Paul Drogaris,Julie Lamontagne,Yiyong Zhou,Julie Piquenot,Sang Tae Park,Sahadevan Raman,Stefan H. E. Kaufmann,Robert P. Mohney,Daniel Chelsky,D. Branch Moody,David R. Sherman,David R. Sherman,Gary K. Schoolnik +46 more
TL;DR: The first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq are taken and system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration is combined.