Mark J. Chen
Salk Institute for Biological Studies
14 Papers
14 Citations
Mark J. Chen is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Mark J. Chen include St. Jude Children's Research Hospital & Genentech.
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Papers
Genomics and evolution of protein phosphatases
TL;DR: The human protein phosphatome is cataloged, composed of 189 known and predicted humanprotein phosphatase genes, and shows similar evolutionary dynamics to those of kinases, with substantial losses in major model organisms.
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Sublethal cytochrome c release generates drug-tolerant persister cells
Halime Kalkavan,Mark J. Chen,Jeremy Chase Crawford,Giovanni Quarato,Patrick Fitzgerald,Stephen W.G. Tait,Colin R. Goding,Douglas R. Green +7 more
TL;DR: In this article , the authors found that sub-lethal mitochondrial outer membrane permeabilization (MOMP) and holocytochrome release are key requirements for the generation of the persister phenotype.
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cBAF complex components and MYC cooperate early in CD8+ T cell fate
Ao Guo,Hon-Chung Huang,Zhexin Zhu,Mark J. Chen,Hao Shi,Sujing Yuan,Piyush Sharma,Jon P. Connelly,Swantje Liedmann,Yogesh Dhungana,Zhenrui Li,Dalia Haydar,Mao Yang,Helen M. Beere,Jason T. Yustein,Christopher DeRenzo,Shondra M. Pruett-Miller,Jeremy Chase Crawford,Giedre Krenciute,Charles W. M. Roberts,Hongbo Chi,Douglas R. Green +21 more
TL;DR: In this article , the authors identify multiple components of the mammalian canonical BRG1/BRM-associated factor (cBAF) and suggest that manipulation of cBAF early in T cell differentiation can improve cancer immunotherapy.
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Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities.
Seema Mattoo,Eric Durrant,Mark J. Chen,Junyu Xiao,Cheri S. Lazar,Gerard Manning,Jack E. Dixon,Jack E. Dixon,Carolyn A. Worby +8 more
TL;DR: Comparative kinetic and phylogenetic analyses of IbpA-Fic2 with the Fic domains of PfhB2, VopS, and HYPE reveal important aspects of their specificities for Rho GTPases and nucleotide usage and offer mechanistic insights for determining nucleotide and substrate specificity for these enzymes.
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Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis
TL;DR: Comparison of the apo and substrate-bound structures of PTPMT1 suggests that it undergoes significant conformational change during catalysis, and it is demonstrated that an evolutionarily conserved EEYE loop is important for its activity.
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