Mark Herbert
John Radcliffe Hospital
18 Papers
195 Citations
Mark Herbert is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Haemophilus influenzae & Gene. The author has an hindex of 14, co-authored 18 publications.
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Papers
Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-1) following Antigen Encounter In Vitro and In Vivo
Tim Willinger,Tom C. Freeman,Mark Herbert,Hitoshi Hasegawa,Andrew J. McMichael,Margaret F. C. Callan +5 more
TL;DR: The data demonstrate that Ag encounter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of LEF1 and TCF7 (TCF-1) expression in human naive CD8 T cells and suggests that proteins involved in the WNT signaling pathway not only regulate T cell development, but also peripheral T cell differentiation.
208
NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae.
Gabriele Kemmer,Thomas J. Reilly,Joachim Schmidt-Brauns,Gary W. Zlotnik,Bruce A. Green,Michael J. Fiske,Mark Herbert,Anita Kraiß,Stefan Schlör,Arnold L. Smith,Joachim Reidl +10 more
TL;DR: The functions and substrates of these two proteins as they act together in an NAD utilization pathway are described, which indicate that NadN harbors not only NAD pyrophosphatase but also NMN 5'-nucleotidase activity.
80
Bacterial virulence factors in neonatal sepsis: group B streptococcus.
TL;DR: Post-genomic knowledge of virulence factors and the organism's metabolism and gene regulation offers opportunities to find novel means of preventing group B streptococcus infection in babies.
53
Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells.
Mariolina Salio,Nicolas Dulphy,Joelle Renneson,Mark Herbert,Andrew J. McMichael,Arnaud Marchant,Vincenzo Cerundolo +6 more
TL;DR: It is demonstrated that, if appropriately activated, neonatal DC can prime efficient cytotoxic T lymphocyte (CTL) responses, which have important implications for the development of vaccine strategies in early life and for the reconstitution of a functional CTL repertoire after bone marrow transplantation.
52
Genetic islands of Streptococcus agalactiae strains NEM316 and 2603VR and their presence in other Group B streptococcal strains
Mark Herbert,Catriona J E Beveridge,David McCormick,Emmelien Aten,Nicola Jones,Lori A. S. Snyder,Nigel J. Saunders +6 more
TL;DR: The notion that GBS strain NEM316 has four putative pathogenicity islands, but none is absolutely necessary for disease causation, whether early- or late-onset sepsis, is supported.