Mark E. Johnson
Baylor College of Medicine
5 Papers
38 Citations
Mark E. Johnson is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Biopsy & Osteosarcoma. The author has an hindex of 5, co-authored 5 publications.
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Papers
Frequent amplification and rearrangement of chromosomal bands 6p12‐p21 and 17p11.2 in osteosarcoma
Ching C. Lau,Charles P. Harris,Xin Yan Lu,Laszlo Perlaky,Sheila Gogineni,Murali Chintagumpala,John Hicks,Mark E. Johnson,Nelson A. Davino,Andrew G. Huvos,Paul A. Meyers,John H. Healy,Richard Gorlick,Pulivarthi H. Rao +13 more
TL;DR: A combination of molecular cytogenetic techniques including comparative genomic hybridization, spectral karyotyping, and fluorescence in situ hybridization to decipher the chromosomal complexity in a panel of 25 tumors found several novel recurrent breakpoint clusters and 9 nonrecurrent reciprocal translocations.
158
Malignant chondroblastoma presenting as a recurrent pelvic tumor with DNA aneuploidy and p53 mutation as supportive evidence of malignancy.
Mary L. Ostrowski,Mark E. Johnson,Luan D. Truong,M. John Hicks,Frank E. Smith,Harlan J. Spjut +5 more
TL;DR: A rare case of malignant chondroblastoma, which presented in a 47-year-old man as a recurrent tumor, 18 years following wide excision of a typical pelvic chondrosarcoma, and which died of disease eight months after presentation is reported.
23
The role of radionuclides in primary musculoskeletal tumors beyond the 'bone scan'.
TL;DR: The unique ability of these radiotracers to demonstrate non-invasively the efflux pump rate, which is a common reason of therapy failure, as well as the metabolic and proliferative rates of the tumors should be a powerful tool in the orthopaedic oncology in the evaluation of musculoskeletal tumors.
12
Low-grade intraosseous osteosarcoma with prominent lymphoid infiltrate.
TL;DR: A proximal tibial low-grade intraosseous osteosarcoma with a prominent intratumoral lymphoid infiltrate led to an initial diagnosis of probable malignant lymphoma, which is free of tumor 1 year after limb salvage surgery.
7
Expression Profiles of Osteosarcoma That Can Predict Response to Chemotherapy
Tsz-Kwong Man,Murali Chintagumpala,Jaya Visvanathan,Jianhe Shen,Laszlo Perlaky,John Hicks,Mark E. Johnson,Nelson A. Davino,Jeffrey C. Murray,Lee J. Helman,William H. Meyer,Timothy J. Triche,Kwong Kwok Wong,Ching C. Lau +13 more
TL;DR: Using parametric two-sample t test, 45 genes that discriminate between good and poor responders are identified and a support vector machine classifier was built using these predictor genes and was tested for its ability to classify initial biopsy samples.