Mark E. Jackson
University of Pittsburgh
15 Papers
368 Citations
Mark E. Jackson is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Prefrontal cortex & Nucleus accumbens. The author has an hindex of 12, co-authored 15 publications. Previous affiliations of Mark E. Jackson include Yale University & Stony Brook University.
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Papers
NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
TL;DR: Using ensemble recording in freely moving rats, it is found that NMDA antagonist treatment, at doses that impaired working memory, potentiated the firing rate of most prefrontal cortex neurons, which provides a physiological basis for the NMDA receptor deficiency model of schizophrenia and may clarify the nature of cortical dysfunction in this disease.
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Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex.
Mark E. Jackson,Bita Moghaddam +1 more
TL;DR: It is suggested that the prefrontal cortex influences the behavioral impact of amygdala activation via a concomitant active suppression of accumbal dopamine release through an inhibitory control by prefrontal cortex on accumbAL dopamine release during amygdala activation.
248
Activation of metabotropic glutamate 2/3 receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats.
TL;DR: Data indicate that activation of mGlu2/3 receptors reduces the disruptive effects of NMDA receptor hypofunction on the spontaneous spike activity and bursting of PFC neurons, which may provide a physiological basis for reversal ofNMDA antagonist-induced behaviors by mGLU2/ 3 agonists.
153
Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens
TL;DR: Results indicate that activation of PFC, at frequencies that are associated with increased cognitive demand on this region, inhibits the mesoaccumbens dopamine system.
148
Glutamatergic Animal Models of Schizophrenia
Bita Moghaddam,Mark E. Jackson +1 more
TL;DR: Several lines of evidence, including recent genetic linkage studies implicating susceptibility genes for schizophrenia, make a strong case that abnormal NMDA receptor‐mediated neurotransmission is a major locus for the pathophysiology of schizophrenia.
140