15 Papers
1 Citations
Mark E. Gill is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Germ cell & DAZL. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Mark E. Gill include Massachusetts Institute of Technology.
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Papers
Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa
Serap Erkek,Mizue Hisano,Ching-Yeu Liang,Ching-Yeu Liang,Mark E. Gill,Rabih Murr,Jürgen Dieker,Dirk Schübeler,Dirk Schübeler,Johan van der Vlag,Michael B. Stadler,Michael B. Stadler,Antoine H.F.M. Peters,Antoine H.F.M. Peters +13 more
TL;DR: The data show evolutionary conservation of the basic principles of nucleosome retention in mouse and human sperm, support a model of epigenetic inheritance by nucleosomes between generations, and observe high enrichment throughout the genome ofucleosomes at CpG-rich sequences that lack DNA methylation.
Germ Cell-Intrinsic and -Extrinsic Factors Govern Meiotic Initiation in Mouse Embryos
TL;DR: It is demonstrated that, in mouse embryos, extrinsic and intrinsic factors together regulate meiotic initiation.
262
Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells
TL;DR: It is proposed that PGCs of both XX and XY fetuses undergo licensing, an active developmental transition that enables the resultant gametogenesis-competent cells to respond to feminizing or masculinizing cues produced by the fetal ovary or testis and hence to embark on oogenesis or spermatogenesis.
198
Retinoic Acid Activates Two Pathways Required for Meiosis in Mice
Jana Koubova,Yueh-Chiang Hu,Tanmoy Bhattacharyya,Y. Q. Shirleen Soh,Mark E. Gill,Mary L. Goodheart,Cathryn A. Hogarth,Michael D. Griswold,David C. Page +8 more
TL;DR: In this article, it was shown that retinoic acid (RA), the extrinsic signal for meiotic initiation, activates transcription of Rec8, which encodes a component of the cohesin complex that accumulates during meiotic S phase.
149
A Gene Regulatory Program for Meiotic Prophase in the Fetal Ovary.
Y. Q. Shirleen Soh,Jan Philipp Junker,Mark E. Gill,Jacob L. Mueller,Alexander van Oudenaarden,David C. Page +5 more
TL;DR: It is proposed that Stra8-independent gene expression enables the stockpiling of selected meiotic structural proteins prior to the commencement of the chromosomal program.