Mark E. DeVries
University at Buffalo
2 Papers
Mark E. DeVries is an academic researcher from University at Buffalo. The author has contributed to research in topics: Protein Data Bank & G protein-coupled receptor. The author has an hindex of 2, co-authored 2 publications.
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Papers
Structure modeling of all identified G protein-coupled receptors in the human genome.
TL;DR: Structural clustering of the predicted models shows that GPCRs with similar structures tend to belong to a similar functional class even when their sequences are diverse, which demonstrates the usefulness and robustness of the in silico models for GPCR functional analysis.
Correction: Structure Modeling of All Identified G Protein-Coupled Receptors in the Human Genome
TL;DR: G protein–coupled receptors (GPCRs), encoded by about 5% of human genes, comprise the largest family of integral membrane proteins and act as cell surface receptors responsible for the transduction of endogenous signal into a cellular response.