Mark D. Spanevello
QIMR Berghofer Medical Research Institute
19 Papers
231 Citations
Mark D. Spanevello is an academic researcher from QIMR Berghofer Medical Research Institute. The author has contributed to research in topics: Ephrin & Erythropoietin-producing hepatocellular (Eph) receptor. The author has an hindex of 15, co-authored 19 publications. Previous affiliations of Mark D. Spanevello include Griffith University & University of Queensland.
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Papers
The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia.
C E de Bock,C E de Bock,Alireza Ardjmand,Timothy J. Molloy,Simon M. Bone,Daniel M. Johnstone,D M Campbell,Kristy L. Shipman,Trina Yeadon,Jeff Holst,Mark D. Spanevello,G Nelmes,Daniel Catchpoole,Lisa F. Lincz,Andrew W. Boyd,Gordon F. Burns,Rick F. Thorne +16 more
TL;DR: In vitro analysis shows that Fat1 protein is expressed by a range of leukemia cell lines, but not by normal peripheral blood (PB) and bone marrow (BM) cells from healthy donors, and could provide a suitable therapeutic target in high-risk preB-ALL.
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Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: Potential as EphA3-specific tumor-targeting reagents
Christopher John Vearing,Fook-Thean Lee,Sabine H Wimmer-Kleikamp,Violeta Spirkoska,Catherine To,Con Stylianou,Mark D. Spanevello,Martin W. Brechbiel,Andrew W. Boyd,Andrew M. Scott,Martin Lackmann +10 more
TL;DR: BIAcore analysis, immunoblot, and confocal microscopy of wild-type and mutant EphA3 with compromised ephrin-A5 or IIIA4-binding capacities indicate thatIIIA4 binding triggers an EPhA3 conformation which is permissive for the assembly of Eph a3/ephrin-A 5-type signaling clusters.
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Cloning and characterisation of Schistosoma japonicum insulin receptors.
Hong You,Wenbao Zhang,Malcolm K. Jones,Malcolm K. Jones,Geoffrey N. Gobert,Jason Mulvenna,Glynn Rees,Mark D. Spanevello,David Blair,Mary Duke,Klaus Brehm,Donald P. McManus +11 more
TL;DR: Adult worms of S. japonicum possess insulin receptors that can specifically bind to insulin, indicating that the parasite can utilize host insulin for development and growth by sharing the same pathway as mammalian cells in regulating glucose uptake.
Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival
Nirmitha I. Herath,James D. Doecke,Mark D. Spanevello,Barbara A. Leggett,Barbara A. Leggett,Andrew W. Boyd,Andrew W. Boyd +6 more
TL;DR: The findings identify EphA1 as a potential prognostic marker in CRC and suggests a potential risk that targeted therapy, by selecting for loss of expression, might contribute to disease progression.
Activation of ephrin A proteins influences hematopoietic stem cell adhesion and trafficking patterns
Michael J. Ting,Michael J. Ting,Bryan W. Day,Mark D. Spanevello,Andrew W. Boyd,Andrew W. Boyd +5 more
TL;DR: Treating bone marrow cells with EphA3-Fc resulted in a reduction by 31% in donor stem cells homing to the bone marrow and accumulation of donor cells in recipient spleens and greater recovery of donorstem cells from the peripheral blood.
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