Mark Bartholomä
Saarland University
74 Papers
452 Citations
Mark Bartholomä is an academic researcher from Saarland University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 16, co-authored 52 publications. Previous affiliations of Mark Bartholomä include Syracuse University & Boston Children's Hospital.
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Papers
Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era.
TL;DR: Mark Daniel Bartholomä was born in Neunkirchen (Germany) and received his diploma (2002) and his doctoral degree (2007) from the Saarland University in Saarbrücken ( Germany) under the supervision of Prof. Kaspar Hegetschweiler on the synthesis and complex formation of multidentate derivatives of 1,3,5-triamino-1,3-5-trideoxy-cis-inositol.
299
Oncogenic JAK2 V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms
Alessandro Prestipino,Alica J. Emhardt,Konrad Aumann,David O’Sullivan,Sivahari P. Gorantla,Sandra Duquesne,Wolfgang Melchinger,Lukas Braun,Slavica Vuckovic,Slavica Vuckovic,Melanie Boerries,Melanie Boerries,Hauke Busch,Hauke Busch,Sebastian Halbach,Sandra Pennisi,Teresa Poggio,Petya Apostolova,Pia Veratti,Pia Veratti,Michael Hettich,Gabriele Niedermann,Mark Bartholomä,Khalid Shoumariyeh,Jonas S. Jutzi,Julius Wehrle,Christine Dierks,Heiko Becker,Annette Schmitt-Graeff,Marie Follo,Dietmar Pfeifer,Jan Rohr,Sebastian Fuchs,Stephan Ehl,Frederike A. Hartl,Susana Minguet,Cornelius Miething,Cornelius Miething,Florian H. Heidel,Nicolaus Kröger,Ioanna Triviai,Tilman Brummer,Jürgen Finke,Anna Lena Illert,Eliana Ruggiero,Chiara Bonini,Justus Duyster,Justus Duyster,Heike L. Pahl,Steven W. Lane,Steven W. Lane,Steven W. Lane,Geoffrey R. Hill,Geoffrey R. Hill,Geoffrey R. Hill,Bruce R. Blazar,Nikolas von Bubnoff,Nikolas von Bubnoff,Erika L. Pearce,Robert Zeiser +59 more
TL;DR: In MPN, constitutive JAK2/STAT3/STAT5 activation, mainly in monocytes, megakaryocytes, and platelets, caused PD-L1–mediated immune escape by reducing T cell activation, metabolic activity, and cell cycle progression, which paving the way for immunomodulatory approaches relying on PD-1 inhibition.
199
Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals.
TL;DR: This work focuses on the design of single amino acid chelates (SAACs), novel bifunctional chelators constructed from derivatized amino acids or amino acid analogues, and affords significant flexibility in the choice of donors for (99m)Tc coordination combined with the considerable advantages of routine solid phase synthetic techniques.
189
Recent developments in the design of bifunctional chelators for metal-based radiopharmaceuticals used in Positron Emission Tomography
TL;DR: This review summarizes the recent developments of bifunctional chelates for two important PET radiometals, copper-64 and gallium-68, and discusses their coordination chemistry in relation to in vivo stability and pharmacokinetics.
134
Gastrin-releasing Peptide Receptor Imaging in Breast Cancer Using the Receptor Antagonist (68)Ga-RM2 And PET.
C. Stoykow,Thalia Erbes,Helmut R. Maecke,Stefan Bulla,Mark Bartholomä,Sebastian Mayer,Vanessa Drendel,Peter Bronsert,Martin Werner,Gerald Gitsch,Wolfgang A. Weber,Elmar Stickeler,Philipp T. Meyer +12 more
TL;DR: In vivo GRPR binding assessed by 68Ga-RM2-PET/CT correlated with ER expression in primary tumors of untreated patients is demonstrated to be a promising imaging method in ER-positive breast cancer.
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