Mark Andrake
Fox Chase Cancer Center
63 Papers
313 Citations
Mark Andrake is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Integrase & Avian sarcoma virus. The author has an hindex of 23, co-authored 56 publications. Previous affiliations of Mark Andrake include Temple University & Medical University of South Carolina.
Chat about Author
Papers
Defects in DNA Repair Genes Predict Response to Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer
Elizabeth R. Plimack,Roland L. Dunbrack,Tim Brennan,Mark Andrake,Yan Zhou,Ilya G. Serebriiskii,Michael Slifker,Katherine Alpaugh,Essel Dulaimi,Norma Alonzo Palma,Jean H. Hoffman-Censits,Marijo Bilusic,Yu-Ning Wong,Alexander Kutikov,Rosalia Viterbo,Richard E. Greenberg,David Y.T. Chen,Costas D. Lallas,Edouard J. Trabulsi,Roman Yelensky,David J. McConkey,Vincent A. Miller,Erica A. Golemis,Eric A. Ross +23 more
TL;DR: A set of genetic mutations that when present in tumor tissue predict benefit from neoadjuvant chemotherapy are found, suggesting that testing before chemotherapy may help in selecting patients for whom this approach is recommended.
505
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
Roshan J. Thapa,Justin P. Ingram,Katherine B Ragan,Shoko Nogusa,David F. Boyd,Asiel Arturo Benitez,Haripriya Sridharan,Rachelle Kosoff,Maria Shubina,Vanessa J Landsteiner,Mark Andrake,Peter Vogel,Luis J. Sigal,Benjamin R. tenOever,Paul G. Thomas,Jason W. Upton,Siddharth Balachandran +16 more
TL;DR: It is reported that DAI (ZBP1/DLM-1), previously implicated as a cytoplasmic DNA sensor, is essential for RIPK3 activation by IAV and implicate DAI as a sensor of RNA viruses.
346
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases
Roshan J. Thapa,Shoko Nogusa,Peirong Chen,Jenny L. Maki,Anthony Lerro,Mark Andrake,Glenn F. Rall,Alexei Degterev,Siddharth Balachandran +8 more
TL;DR: It is shown that both type I (α/β) and type II (γ) IFNs induce precipitous receptor-interacting protein (RIP)1/RIP3 kinase-mediated necrosis when the adaptor protein Fas-associated death domain (FADD) is lost or disabled by phosphorylation, or when caspases are inactivated.
341
Retroviral Integrase, Putting the Pieces Together
Mark Andrake,Anna Marie Skalka +1 more
TL;DR: Retroviral integrase mediates retroviral DNA integration, a critical step in viral replication that ensures stable expression of proviral genes in the infected cell and perpetuation of the viral genome in all the host cell progeny.
135
HMG Protein Family Members Stimulate Human Immunodeficiency Virus Type 1 and Avian Sarcoma Virus Concerted DNA Integration In Vitro
TL;DR: Reconstituted concerted human immunodeficiency virus type 1 (HIV-1) integration in vitro with specially designed mini-donor HIV-1 DNA, a supercoiled plasmid acceptor, purified bacterium-derived HIV- 1 integrase (IN), and host HMG protein family members demonstrates that the stimulation of integration requires an HMG-I(Y) domain involved in DNA binding.
131