Mark A. Wallet
University of Florida
38 Papers
65 Citations
Mark A. Wallet is an academic researcher from University of Florida. The author has contributed to research in topics: T cell & Biology. The author has an hindex of 20, co-authored 35 publications. Previous affiliations of Mark A. Wallet include University of North Carolina at Chapel Hill.
Chat about Author
Papers
Apoptotic cells induce Mer tyrosine kinase–dependent blockade of NF-κB activation in dendritic cells
Pradip Sen,Mark A. Wallet,Zuoan Yi,Yingsu Huang,Michael A. Henderson,Clayton E. Mathews,H. Shelton Earp,Glenn K. Matsushima,Albert S. Baldwin,Roland Tisch +9 more
TL;DR: An essential role for MerTK-mediated regulation of the PI3K/AKT and NF-kappaB pathways in AC-induced inhibition of monocyte-derived DCs is demonstrated.
227
Immunoregulation of Dendritic Cells
TL;DR: The paradigm of tolerogenic/immature versus inflammatory/mature dendritic cells has dominated the recent literature regarding the role of these antigen-presenting cells in mediating immune homeostasis or self-tolerance and response to pathogens, respectively.
Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IκB kinase activity
TL;DR: It is demonstrated that IL-10 targets IKK activation in immature DCs and that suppressing the PI3K pathway in part mediates blockade of the pathway.
175
Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection
Matthew J. Delano,Terri C. Thayer,Sonia Gabrilovich,Kindra M. Kelly-Scumpia,Robert D. Winfield,Philip O. Scumpia,Alex G. Cuenca,Elizabeth A. Warner,Shannon M. Wallet,Mark A. Wallet,Kerri A. O’Malley,Reuben Ramphal,Michael Clare-Salzer,Philip A. Efron,Clayton E. Mathews,Lyle L. Moldawer +15 more
TL;DR: It is demonstrated that sepsis promotes selective early, impaired innate immune responses, primarily in neutrophils, that lead to a pathogen-specific, increased susceptibility to secondary infections.
MerTK is required for apoptotic cell–induced T cell tolerance
Mark A. Wallet,Pradip Sen,Rafael Flores,Yaming Wang,Zuoan Yi,Yingsu Huang,Clayton E. Mathews,H. Shelton Earp,Glenn K. Matsushima,Bo Wang,Roland Tisch +10 more
TL;DR: Evidence that the receptor tyrosine kinase Mer (MerTK) has a key role in mediating AC-induced inhibition of DC activation/maturation is presented, demonstrating that MerTK plays a critical role in regulating self-tolerance mediated between ACs, DCs, and T cells.
151