Mark A. Stagg
National Institutes of Health
21 Papers
295 Citations
Mark A. Stagg is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Contractility & Transplantation. The author has an hindex of 12, co-authored 21 publications. Previous affiliations of Mark A. Stagg include Imperial College London & Harefield Hospital.
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Papers
Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure.
Gopal K. Soppa,Joon Ha Lee,Mark A. Stagg,Leanne E. Felkin,Paul J.R. Barton,Urszula Siedlecka,Samuel Youssef,Magdi H. Yacoub,Cesare M. Terracciano +8 more
TL;DR: Clenbuterol treatment of failing rat hearts, alone or in combination with mechanical unloading, improves LV function at the whole-heart and cellular levels by affecting cell morphology, excitation–contraction coupling, and myofilament sensitivity to calcium.
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Cytoskeletal Protein 4.1R Affects Repolarization and Regulates Calcium Handling in the Heart
Mark A. Stagg,Edward A. Carter,Nadia Sohrabi,Urszula Siedlecka,Gopal K. Soppa,Fiona Mead,Narla Mohandas,Pamela M. Taylor-Harris,Anthony J. Baines,Pauline M. Bennett,Magdi H. Yacoub,Jennifer C. Pinder,Cesare M. Terracciano +12 more
TL;DR: An unexpected and novel role for the cytoskeletal protein 4.1R in modulating the functional properties of several cardiac ion transporters with consequences on cardiac electrophysiology and with possible significant roles during normal cardiac function and disease is indicated.
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The red wine polyphenol, resveratrol, exerts acute direct actions on guinea-pig ventricular myocytes.
TL;DR: The findings provide evidence that resveratrol exerts multiple direct actions on cardiac myocytes, the net result of which is no overall change in cell contraction, and the clinical significance of these results remains to be determined.
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Prolonged mechanical unloading reduces myofilament sensitivity to calcium and sarcoplasmic reticulum calcium uptake leading to contractile dysfunction.
Gopal K. Soppa,Joon Ha Lee,Mark A. Stagg,Urszula Siedlecka,Samuel Youssef,Magdi H. Yacoub,Cesare M. Terracciano +6 more
TL;DR: Prolonged myocardial unloading causes depressed contractility due to reduced SR Ca( 2+) uptake and myofilament sensitivity to Ca(2+).
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Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation
Mark A. Stagg,Steven R. Coppen,Ken Suzuki,Anabel Varela-Carver,Joon Ha Lee,Nigel J. Brand,Satsuki Fukushima,Magdi H. Yacoub,Cesare M. Terracciano +8 more
TL;DR: The overexpression of Cx43 in SMs increased the formation of electrical communication and the steady‐state conductance between SMs and CMs and enhanced gap junctional conductance may be useful to promote the integration of transplanted SMs into the myocardium.
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