Mark A. MacInnes
Los Alamos National Laboratory
12 Papers
289 Citations
Mark A. MacInnes is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Nucleotide excision repair & DNA repair. The author has an hindex of 10, co-authored 12 publications.
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Papers
The DNA Repair Endonuclease XPG Binds to Proliferating Cell Nuclear Antigen (PCNA) and Shares Sequence Elements with the PCNA-binding Regions of FEN-1 and Cyclin-dependent Kinase Inhibitor p21
TL;DR: The direct physical interaction of PCNA with xeroderma pigmentosum (XP) G, a structure-specific repair endonuclease that is homologous to FEN-1, raises the possibility of a mechanistic linkage between excision and repair synthesis that is mediated by PCNA.
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Two essential but distinct functions of the mammalian abasic endonuclease.
Tadahide Izumi,Tadahide Izumi,David Brown,C. V. Naidu,C. V. Naidu,Kishor K. Bhakat,Mark A. MacInnes,Hiroshi Saito,David J. Chen,Sankar Mitra +9 more
TL;DR: The results indicate that distinct and separable functions of APE1 are both essential for mammalian cells even in vitro and provide the evidence that mammalian cells, unlike yeast or Escherichia coli, absolutely require APE for survival, presumably to protect against spontaneous oxidative DNA damage.
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A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity
Dale L. Ludwig,Mark A. MacInnes,Yuichi Takiguchi,Paige E. Purtymun,Melinda Henrie,Margaret L. Flannery,Juanito J. Meneses,Roger A. Pedersen,David J. Chen +8 more
TL;DR: This study establishes that this new Ape/Ref deficiency genotype is definitely capable of post-implantation developmental progression to the onset of gastrulation.
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The Dynamic Alterations of H2AX Complex during DNA Repair Detected by a Proteomic Approach Reveal the Critical Roles of Ca2+/Calmodulin in the Ionizing Radiation-induced Cell Cycle Arrest
Yu Chun Du,Sheng Gu,Jianhong Zhou,Tianyi Wang,Hong Cai,Mark A. MacInnes,E. Morton Bradbury,Xian Chen +7 more
TL;DR: The results suggest that the H2AX complex undergoes dynamic changes upon induction of DNA damage and during DNA repair, and indicates that Ca2+/CaM plays important roles in regulating IR-induced cell cycle arrest, possibly through mediating chromatin structure.
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Ultraviolet-induced movement of the human DNA repair protein, Xeroderma pigmentosum type G, in the nucleus
Min S. Park,Jeffrey A. Knauf,Stephanie H. Pendergrass,Christopher H. Coulon,Gary F. Strniste,Babetta L. Marrone,Mark A. MacInnes +6 more
TL;DR: A novel dynamics of this protein within the cell nucleus after UV irradiation of human cells is described, leading to a model in which distribution of XPG protein may regulate the rate of DNA repair within transcriptionally active and inactive compartments of thecell nucleus.
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