Mark A. Czuczman
University of Toronto
5 Papers
Mark A. Czuczman is an academic researcher from University of Toronto. The author has contributed to research in topics: Listeriolysin O & Innate immune system. The author has an hindex of 4, co-authored 5 publications.
Chat about Author
Papers
Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread
Mark A. Czuczman,Ramzi Fattouh,Jorik M. van Rijn,Veronica Canadien,Suzanne E. Osborne,Aleixo M. Muise,Vijay K. Kuchroo,Darren E. Higgins,John H. Brumell +8 more
TL;DR: It is shown that protrusion formation is associated with plasma membrane damage due to LLO’s pore-forming activity, indicating that PS-targeted therapeutics may be useful in the fight against infections by L. monocytogenes and other bacteria that use similar strategies of cell-to-cell spread during infection.
An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.
Joel M J Tan,Nora Mellouk,Suzanne E. Osborne,Dustin A. Ammendolia,Diana N Dyer,Ren Li,Diede Brunen,Jorik M. van Rijn,Ju Huang,Mark A. Czuczman,Marija Cemma,Amy Won,Christopher M. Yip,Ramnik J. Xavier,Donna A. MacDuff,Fulvio Reggiori,Fulvio Reggiori,Jayanta Debnath,Tamotsu Yoshimori,Peter K. Kim,Gregory D. Fairn,Gregory D. Fairn,Etienne Coyaud,Brian Raught,Brian Raught,Aleixo M. Muise,Darren E. Higgins,John H. Brumell +27 more
TL;DR: It is shown that autophagy-related protein ATG16L1 and its binding partners ATG5 and ATG12 are required for plasma membrane repair through a pathway independent of macroautophagy, and help to restrict Listeria monocytogenes toxin-mediated cell-to-cell spread.
64
•Dissertation
A Novel Role of Listeriolysin O in the Exit of Listeria monocytogenes from Host Cells during Infection
Mark A. Czuczman
- 01 Nov 2013
TL;DR: It is suggested that within the context of a youth-services agency using a mobile app to provide real-time information about earthquake-triggered landsliding and liquefaction is a viable process.
Interactions of Listeria monocytogenes with the autophagy system of host cells.
TL;DR: An underappreciated population of L. monocytogenes that can replicate in macrophage vacuoles is discussed and how these may be important for the establishment of chronic infections.
The Diaphanous-Related Formins Promote Protrusion Formation and Cell-to-Cell Spread of Listeria monocytogenes
Ramzi Fattouh,Hyunwoo Kwon,Mark A. Czuczman,John W. Copeland,Laurence Pelletier,Margot E. Quinlan,Aleixo M. Muise,Darren E. Higgins,John H. Brumell +8 more
TL;DR: A Rho GTPase-formin network that is critically involved in the cell-to-cell spread of L. monocytogenes is identified and knockdown of several Rho family members significantly influenced bacterial cell- to- cell spread.