Marja Saarinen
University of California, Los Angeles
5 Papers
63 Citations
Marja Saarinen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Salmonella & Cytokine. The author has an hindex of 5, co-authored 5 publications.
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Papers
Invasion of Salmonella into human intestinal epithelial cells is modulated by HLA‐B27
Marja Saarinen,P. Ekman,M. Ikeda,M. Virtala,A. Grönberg,D. T. Y. Yu,H. Arvilommi,Kaisa Granfors +7 more
TL;DR: It is suggested that HLA-B27 enhances the invasion of Salmonella into intestinal epithelial cells, which may lead to an increased load ofSalmonella in intestinal tissue and thus increased susceptibility to reactive arthritis.
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HLA-B27-Transfected (Salmonella Permissive) and HLA-A2-Transfected (Salmonella Nonpermissive) Human Monocytic U937 Cells Differ in Their Production of Cytokines
Päivi Ekman,Marja Saarinen,Qiushui He,Christel Gripenberg-Lerche,Alvar Grönberg,Heikki Arvilommi,Kaisa Granfors +6 more
TL;DR: Salmonella-permissive U937 cells showed upregulated production of interleukin 10 and to a lesser extent tumor necrosis factor alpha, suggesting HLA-B27-associated modulation of cytokine responses may have importance in the pathogenesis of reactive arthritis.
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Human monocytic U937 cells kill Salmonella in vitro by NO-independent mechanisms
TL;DR: Both human monocytic transfectants produced NO equally well and killed Salmonella via NO-independent mechanisms and this study studied whether impaired elimination of Salmoneella would result from differences in NO production between HLA-B27- and Hla-A2-transfected U937 cells.
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Survival and degradation of Salmonella enterica serotype Enteritidis in intestinal epithelial cells in vitro.
TL;DR: The results suggest that in patients developing reactive arthritis the salmonellae could persist in the epithelial cells and spread within the host to the joint and be present there at the time of the inflammatory response.
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Elimination of Salmonella enterica serotype Enteritidis in intestinal epithelial cells by mechanisms other than nitric oxide
Marja Saarinen,Päivi Ekman,Qiushui He,Makoto Ikeda,Mika Virtala,David T. Y. Yu,Heikki Arvilommi,Kaisa Granfors +7 more
TL;DR: The data suggest that NO does not have a direct role in the elimination of intracellular Salmonellae by human intestinal epithelial cells.
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