Marius Vantler
University of Cologne
29 Papers
137 Citations
Marius Vantler is an academic researcher from University of Cologne. The author has contributed to research in topics: Platelet-derived growth factor receptor & Pulmonary hypertension. The author has an hindex of 13, co-authored 21 publications.
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Papers
Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation.
Henrik ten Freyhaus,Michael Huntgeburth,Kirstin Wingler,Jessika Schnitker,Anselm T. Bäumer,Marius Vantler,Mohamed M. Bekhite,Maria Wartenberg,Heinrich Sauer,Stephan Rosenkranz +9 more
TL;DR: VAS2870 effectively suppresses growth factor-mediated ROS liberation in VSMC and completely inhibits PDGF-dependent VSMC migration, whereas it does not affect DNA synthesis.
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Phosphatidylinositol 3-Kinase-dependent Membrane Recruitment of Rac-1 and p47phox Is Critical for α-Platelet-derived Growth Factor Receptor-induced Production of Reactive Oxygen Species
Anselm T. Bäumer,Henrik ten Freyhaus,Heinrich Sauer,Maria Wartenberg,Kai Kappert,Petra Schnabel,Christian Konkol,Jürgen Hescheler,Marius Vantler,Stephan Rosenkranz +9 more
TL;DR: It is concluded that PI3K/p110α mediates growth factor-dependent ROS production by recruiting p47phox and Rac-1 to the cell membrane, thereby assembling the active Nox complex.
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Imatinib mesylate for the treatment of pulmonary arterial hypertension.
Henrik ten Freyhaus,Daniel Dumitrescu,Eva Berghausen,Marius Vantler,Evren Caglayan,Stephan Rosenkranz +5 more
TL;DR: This review delineates the current limitations in the management of PAH and focuses on a novel, anti-proliferative therapeutic concept, imatinib mesylate, which potently inhibits the PDGF receptor, as an additional treatment option in PAH.
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Systematic Evaluation of Anti-apoptotic Growth Factor Signaling in Vascular Smooth Muscle Cells: ONLY PHOSPHATIDYLINOSITOL 3′-KINASE IS IMPORTANT *
TL;DR: It is concluded that growth factor-dependent cell survival in VSMC is mediated only by activation of the PI3K/Akt pathway, whereas all other receptor-associated signaling molecules do not play a significant role.
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PDGF-BB protects cardiomyocytes from apoptosis and improves contractile function of engineered heart tissue.
Marius Vantler,Bijoy Chandapillai Karikkineth,Hiroshi Naito,Malte Tiburcy,Malte Tiburcy,Michael Didié,Michael Didié,Monika Nose,Stephan Rosenkranz,WH Zimmermann,WH Zimmermann +10 more
TL;DR: PDGF-BB does not induce hypertrophy or proliferation, but confers an anti-apoptotic effect on cardiomyocytes, and the findings suggest a further exploitation of PDGF- BB inCardiomyocyte protection in vivo and in vitro.
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