Marius Döring
Hannover Medical School
14 Papers
92 Citations
Marius Döring is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 8, co-authored 11 publications.
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Papers
Morbillivirus Control of the Interferon Response: Relevance of STAT2 and mda5 but Not STAT1 for Canine Distemper Virus Virulence in Ferrets
Nicholas Svitek,Ingo Gerhauser,Ingo Gerhauser,Christophe Goncalves,Elena Grabski,Marius Döring,Ulrich Kalinke,Danielle E. Anderson,Roberto Cattaneo,Veronika von Messling,Veronika von Messling,Veronika von Messling +11 more
TL;DR: This study demonstrates the importance of interference with STAT2 and mda5 signaling for CDV immune evasion and provides a starting point for the development of morbillivirus vectors with reduced immunosuppressive properties.
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Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets.
Hanna Fischbach,Marius Döring,Daphne Nikles,Elisa Lehnert,Christoph Baldauf,Ulrich Kalinke,Robert Tampé +6 more
TL;DR: An innovative flow cytometric approach to monitor time-resolved ER compartmentalization of antigenic peptides and permits quantification of TAP activity under close to physiological conditions in scarce primary cell subsets such as antigen cross-presenting dendritic cells.
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M27 Expressed by Cytomegalovirus Counteracts Effective Type I Interferon Induction of Myeloid Cells but Not of Plasmacytoid Dendritic Cells
Marius Döring,Irina Lessin,Theresa Frenz,Julia Spanier,Annett Kessler,Pia K. Tegtmeyer,Franziska Dağ,Nadine Thiel,Mirko Trilling,Stefan Lienenklaus,Siegfried Weiss,Stefanie Scheu,Martin Messerle,Luka Cicin-Sain,Hartmut Hengel,Ulrich Kalinke +15 more
TL;DR: It is found that additional MCMV-encoded evasins were needed to efficiently shut off IFN-I responses of macrophages, but not of myeloid dendritic cells, thus further elucidating the subtle adjustment of the host-pathogen balance.
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A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle
Tony Matschulla,Richard Berry,Carolin Gerke,Marius Döring,Julia Busch,Jennifer Paijo,Ulrich Kalinke,Frank Momburg,Hartmut Hengel,Anne Halenius +9 more
TL;DR: Understanding of the molecular mechanism underpinning TAP inhibition by ICP47 is broadened, to include the 50PLL52 sequence as a stabilizer that tethers the TAP-ICP47 complex in an inward-facing conformation.
Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.
Marius Döring,Hanna Blees,Nicole Koller,Sabine Tischer-Zimmermann,Mathias Müsken,Frederik Henrich,Frederik Henrich,Jennifer Becker,Elena Grabski,Junxi Wang,Hans Janssen,Werner Zuschratter,Jacques Neefjes,Frank Klawonn,Britta Eiz-Vesper,Robert Tampé,Ulrich Kalinke +16 more
TL;DR: It is found that monocytes showed high transporter associated with antigen processing (TAP)-dependent peptide compartmentalization and that after antigen pulsing, they were not able to efficiently stimulate antigen-specific T lymphocytes, compatible with the model that during monocyte-to-DC differentiation, the subcellular relocation of TAP and the regulation of its activity assure spatiotemporal separation of local antigen uptake and processing by monocytes.
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