Maritza Lienlaf
Albert Einstein College of Medicine
4 Papers
160 Citations
Maritza Lienlaf is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: HAMP domain & Cyclic nucleotide-binding domain. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.
Maritza Lienlaf,Fumiaki Hayashi,Francesca Di Nunzio,Naoya Tochio,Takanori Kigawa,Shigeyuki Yokoyama,Felipe Diaz-Griffero +6 more
TL;DR: A role for TRIM5α self-ubiquitylation in the ability of TRIM7α to restrict HIV-1 is demonstrated and several residues, particularly the ones on the E2-binding region of the RING domain, were defective in their self-ubsiclation ability.
85
RING Domain Mutations Uncouple TRIM5α Restriction of HIV-1 from Inhibition of Reverse Transcription and Acceleration of Uncoating
Amanda Roa,Fumiaki Hayashi,Yang Yang,Maritza Lienlaf,Jing Zhou,Jiong Shi,Satoru Watanabe,Takanori Kigawa,Shigeyuki Yokoyama,Christopher Aiken,Felipe Diaz-Griffero +10 more
TL;DR: It is suggested that TRIM5αrh blocks HIV-1 reverse transcription by inducing premature viral uncoating in target cells by correlated the block of reverse transcription with the ability of TRim5α to accelerate un coating.
82
A Phase I/II Trial Evaluating The Use Of a Histone Deacetylase Inhibitor Panobinostat (LBH589) In Addition To Glucocorticoids In Patients With Acute Graft-Versus-Host Disease
Lia Perez,Teresa Field,Marcie L. Riches,Hugo F. Fernandez,Frederick L. Locke,Brian C. Betts,Joseph Pidala,Erika Elmer,Francisca Beato,Maritza Lienlaf,Pedro Horna,Alejandro Villagra,Claudio Anasetti +12 more
TL;DR: It is concluded that more effective acute GVHD therapy might improve remission rates that will result in better survival after allogeneic HCT and a role HDACi Panobinostat as a tool to improve success of glucocorticoids for GV HD treatment is suggested.
4
TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core
Jose Carlos Valle-Casuso,Francesca Di Nunzio,Yang Yang,Natalia Reszka,Maritza Lienlaf,Nathalie J. Arhel,Patricio Perez,Abraham L. Brass,Felipe Diaz-Griffero +8 more
TL;DR: It is shown that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration, which suggests thatTNPO3 interacts with the incoming HIV-2 core in the cytoplasm to assist a process that is important for HIV- 1 infection after nuclear imported.