Maristella Tassi
University of Siena
15 Papers
295 Citations
Maristella Tassi is an academic researcher from University of Siena. The author has contributed to research in topics: T cell & IGHV@. The author has an hindex of 9, co-authored 15 publications.
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Papers
The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors.
Davide Rossi,Elisa Sozzi,Alessia Puma,Lorenzo De Paoli,Silvia Rasi,Valeria Spina,Alessandro Gozzetti,Maristella Tassi,Emanuele Cencini,Donatella Raspadori,Valeria Pinto,Francesco Bertoni,Valter Gattei,Francesco Lauria,Gianluca Gaidano,Francesco Forconi +15 more
TL;DR: Overall, data showed that cMBL has a more favourable clinical course than Rai 0 CLL, and stratification based on biological prognosticators may be helpful forcMBL management.
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Lipid rafts and T cell receptor signaling: a critical re-evaluation.
Paola Pizzo,Emanuele Giurisato,Maristella Tassi,Angelo Benedetti,Tullio Pozzan,Antonella Viola +5 more
TL;DR: The results indicate that, while signaling through GPI‐anchored proteins requires lipid raft integrity, CD3‐dependent TCR activation occurs independently of cholesterol extraction.
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Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products
Alessandra Gamberucci,Emanuele Giurisato,Paola Pizzo,Maristella Tassi,Roberta Giunti,Deirdre Patricia McINTOSH,Angelo Benedetti +6 more
TL;DR: It is concluded that T-cells express a diacylglycerol-activated cation channel, unrelated to the channel involved in capacitative Ca(2+) entry, and associated with the expression of TRP6 protein.
T cell receptor can be recruited to a subset of plasma membrane rafts, independently of cell signaling and attendantly to raft clustering.
Emanuele Giurisato,Deirdre Patricia McINTOSH,Maristella Tassi,Alessandra Gamberucci,Angelo Benedetti +4 more
TL;DR: It is suggested that during T cell stimulation a lateral reorganization of rafts into polarized larger domains can determine the recruitment of TCR into these domains, which favors a polarization of the signaling cascade.
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Physiological T cell activation starts and propagates in lipid rafts.
Paola Pizzo,Emanuele Giurisato,Anna Bigsten,Maristella Tassi,Regina Tavano,Andrey S. Shaw,Antonella Viola +6 more
TL;DR: It is shown that, in contrast to T cell stimulation by anti-CD3 antibodies, T cell activation by a physiological ligand is mediated by signaling events taking place in lipid raft, where the signal transduction is organized and amplified.
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