Mariska Klepper
Erasmus University Rotterdam
45 Papers
168 Citations
Mariska Klepper is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Transplantation & CD8. The author has an hindex of 13, co-authored 39 publications. Previous affiliations of Mariska Klepper include Erasmus University Medical Center.
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Papers
The effect of the JAK inhibitor CP-690,550 on peripheral immune parameters in stable kidney allograft patients
Evelien A. F. J. van Gurp,Wenda Schoordijk-Verschoor,Mariska Klepper,Sander S. Korevaar,G. Chan,Willem Weimar,Carla C. Baan +6 more
TL;DR: The role of JAK3 in the homeostasis and function of select lymphocyte subpopulations is demonstrated and may provide a novel mechanism for the modulation of allogeneic responses in patients after transplantation.
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The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients
Anne P. Bouvy,Mariska Klepper,Marcia M. L. Kho,Karin Boer,Michiel G. H. Betjes,Willem Weimar,Carla C. Baan +6 more
TL;DR: In kidney transplant patients, repopulation of Treg after rATG and basiliximab therapy is the result of homeostatic proliferation and not of thymopoiesis.
Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation
Burç Dedeoglu,Ruud W. J. Meijers,Mariska Klepper,Dennis A. Hesselink,Carla C. Baan,Nicolle H.R. Litjens,Michiel G. H. Betjes +6 more
TL;DR: Immunological ageing-related expansion of highly differentiated CD28null T cells is associated with a lower risk for early acute allograft rejection in end-stage renal disease patients.
Peripheral blood manipulation significantly affects the result of dendritic cell monitoring.
Jeroen H. Gerrits,P Athanassopoulos,Lenard M.B. Vaessen,Mariska Klepper,Willem Weimar,Nicole M. van Besouw +5 more
TL;DR: The pDC/mDC ratio and pDC or mDC maturation status based on CKR expression, is dependent on manipulation of PBMCs, and fresh blood is preferable for monitoring purposes in transplant patients, as only these cells reflect the in vivo immune-status of patients accurately.
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Functional CD25bright+ alloresponsive T cells in fully immunosuppressed renal allograft recipients
Carla C. Baan,Jurjen H. L. Velthuis,Evelien A. F. J. van Gurp,W. M. Mol,Mariska Klepper,Jan N. M. IJzermans,Willem Weimar +6 more
TL;DR: Evidence from animal studies indicate a crucial role for CD25bright+ regulatory T cells in transplantation tolerance, and this work aims to extend this role to T-cell reprograming in mice.
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