Marino De Leon
Loma Linda University
49 Papers
160 Citations
Marino De Leon is an academic researcher from Loma Linda University. The author has contributed to research in topics: Apoptosis & Type 2 diabetes. The author has an hindex of 21, co-authored 47 publications. Previous affiliations of Marino De Leon include University of California, Davis.
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Papers
Palmitic and stearic fatty acids induce caspase-dependent and -independent cell death in nerve growth factor differentiated PC12 cells
TL;DR: Findings are consistent with the hypothesis that FFAs may play a role in the cell death associated with trauma in the CNS and PNS, and an up‐regulation of the Fas receptor and ligand mRNA.
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Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75
Melanie Mediavilla-Varela,Fabio J. Pacheco,Frankis Almaguel,Jossymar Perez,Eva Sahakian,Tracy R. Daniels,Lai Sum Leoh,Amelia Padilla,Nathan R. Wall,Michael B. Lilly,Michael B. Lilly,Marino De Leon,Carlos A. Casiano +12 more
TL;DR: The results underscore the ability of docetaxel to induce concomitantly caspase-dependent and independent death pathways in prostate cancer cells and point to LEDGF/p75 as a potential contributor to cellular resistance to docetxel-induced lysosomal destabilization and cell death, and an attractive candidate for molecular targeting in HRPC.
Underrepresented Minority High School and College Students Report STEM-Pipeline Sustaining Gains After Participating in the Loma Linda University Summer Health Disparities Research Program
TL;DR: It is concluded that structured SREs can be highly effective STEM strengthening interventions for both UG and HS students and may be a way to measurably increase institutional and biomedical workforce diversity.
114
Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β
Dequina A. Nicholas,Kangling Zhang,Christopher Hung,Shane Glasgow,Aruni Wilson Aruni,Juli Unternaehrer,Kimberly J. Payne,William H. R. Langridge,Marino De Leon +8 more
TL;DR: The experiments demonstrate for the first time that PA activation of TLR4 occurs in response to direct molecular interactions between PA and MD-2, suggesting a likely molecular mechanism for PA induction of pro-inflammatory immune responses in human dendritic cells expressingTLR4.
Differential Expression of Peroxiredoxins in Prostate Cancer: Consistent Upregulation of PRDX3 and PRDX4
Anamika Basu,Hiya Banerjee,Heather Rojas,Shannalee R. Martinez,Sourav Roy,Zhenyu Jia,Michael B. Lilly,Marino De Leon,Carlos A. Casiano +8 more
TL;DR: The peroxiredoxins (PRDXs) are emerging as regulators of antioxidant defense, apoptosis, and therapy resistance in cancer and their significance in prostate cancer is unclear.
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