Marine Frezza
University of Lyon
9 Papers
98 Citations
Marine Frezza is an academic researcher from University of Lyon. The author has contributed to research in topics: Quorum sensing & Homoserine. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Marine Frezza include Institut national des sciences Appliquées de Lyon & École supérieure de chimie physique électronique de Lyon.
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Papers
Synthesis and Biological Evaluation of the Trifluoromethyl Analog of (4S)‐4,5‐Dihydroxy‐2,3‐pentanedione (DPD)
Marine Frezza,Damien Balestrino,Laurent Soulère,Sylvie Reverchon,Yves Queneau,Christiane Forestier,Alain Doutheau +6 more
TL;DR: In this paper, the trifluoromethyl group was introduced by treating (trifluorsyl)trimethylsilane with an α-methylene ester resulting from a Baylis-Hillman reaction between (tert-butyldimethylsilyloxy)acetaldehyde and a vinylamide derived from Oppolzer's sultam reagent.
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Exploring the active site of acyl homoserine lactones-dependent transcriptional regulators with bacterial quorum sensing modulators using molecular mechanics and docking studies.
Laurent Soulère,Marine Frezza,Marine Frezza,Marine Frezza,Yves Queneau,Yves Queneau,Yves Queneau,Alain Doutheau,Alain Doutheau,Alain Doutheau +9 more
TL;DR: Tyr53, Tyr61 and Asp70, conserved residues, are implicated in both the development of additional hydrogen bonds and attractive interactions with the N-sulfonyl homoserine lactones and AHLs derived ureas antagonists.
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Ac2-DPD, the bis-(O)-acetylated derivative of 4,5-dihydroxy-2,3-pentanedione (DPD) is a convenient stable precursor of bacterial quorum sensing autoinducer AI-2
Marine Frezza,Laurent Soulère,Damien Balestrino,Michel Gohar,Christian Deshayes,Yves Queneau,Christiane Forestier,Alain Doutheau +7 more
TL;DR: By contrast with DPD, Ac2-DPD proved to be a stable compound which can be purified and stored and showed the same ability as DPD to induce bioluminescence in Vibrio harveyi and beta-galactosidase activity in Salmonella enterica Typhimurium.
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A Baylis–Hillman/ozonolysis route towards (±) 4,5-dihydroxy-2,3-pentanedione (DPD) and analogues
TL;DR: The Baylis-Hillman reaction between 2-( tert -butyldimethylsilyloxy)ethanal and 3-buten-2-one followed by desilylation gave rise to the corresponding α-methylene-β,γ-dihydroxy ketone further converted by reductive ozonolysis of the carbon-carbon double bond into racemic 4,5-dhydroxy-2,3-pentanedione (DPD ), a significant molecule in bacterial cell-cell communication systems as mentioned in this paper.
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A Baylis—Hillman/Ozonolysis Route Towards (.+-.) 4,5-Dihydroxy-2,3-pentanedione (DPD) and Analogues.
TL;DR: The Baylis-Hillman reaction between 2-( tert -butyldimethylsilyloxy)ethanal and 3-buten-2-one followed by desilylation gave rise to the corresponding α-methylene-β,γ-dihydroxy ketone further converted by reductive ozonolysis of the carbon-carbon double bond into racemic 4,5-dhydroxy-2,3-pentanedione (DPD ), a significant molecule in bacterial cell-cell communication systems as discussed by the authors.
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